76464-51-2Relevant academic research and scientific papers
3-Amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile
Scott, David A.,Bell, Kirsten J.,Campbell, Cheryl T.,Cook, Donald J.,Dakin, Les A.,Del Valle, David J.,Drew, Lisa,Gero, Thomas W.,Hattersley, Maureen M.,Omer, Charles A.,Tyurin, Boris,Zheng, Xiaolan
scheme or table, p. 701 - 705 (2009/08/15)
The optimization of compounds from the 3-amido-4-anilinoquinolines series of CSF-1R kinase inhibitors is described. The series has excellent activity and kinase selectivity. Excellent physical properties and rodent PK profiles were achieved through the introduction of cyclic amines at the quinoline 6-position. Compounds with good activity in a mouse PD model measuring inhibition of pCSF-1R were identified.
MODULATORS OF AMYLOID BETA
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Page/Page column 22, (2011/07/06)
The invention relates to compounds of formula wherein hetaryl I, hetaryl II, and R1 are as described herein. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease.
