76464-92-1

Basic information

• Product Name: N-ethyl-2-iodobenzylamine
• Synonyms: N-ethyl-2-iodobenzylamine
• CAS NO: 76464-92-1
• Molecular Weight: 261.105
• Mol File: 76464-92-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-ethyl-2-iodobenzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyl-2-iodobenzylamine(76464-92-1)
• EPA Substance Registry System: N-ethyl-2-iodobenzylamine(76464-92-1)

Safety Data

• Hazardous Substances Data: 76464-92-1(Hazardous Substances Data)

Upstream product

• 26260-02-6 2-iodobenzaldehyde 
• 75-04-7 ethylamine 

Downstream Products

• 137522-30-6 2-Ethyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-4-ol 
• 140420-09-3 2-(Benzyl-ethyl-amino)-1-phenyl-ethanone 
• 158692-72-9 N-(2-Iodobenzyl)-N-ethyl((4-methylphenyl)sulfonyl)acetamide 
• 158692-80-9 N-(2-Iodobenzyl)-N-ethylchloroacetamide 
• 158692-68-3 N-(2-Iodobenzyl)-N-ethylcyanoacetamide 
• 137522-24-8 2-[Ethyl-(2-iodo-benzyl)-amino]-1-phenyl-ethanone 

Relevant articles and documents

Synthesis of 3,4-Fused Tricyclic Indoles through Cascade Carbopalladation and C-H Amination: Development and Total Synthesis of Rucaparib

3,4-Fused tricyclic indole scaffolds are ubiquitous in bioactive natural products and pharmaceuticals. A new protocol for the synthesis of 3,4-fused tricyclic indoles has been developed through cascade carbopalladation and C-H amination with N,N-di-tert-butyldiaziridinone. The protocol allows access to a range of 3,4-fused tricyclic indoles, including those containing various linkers and fused with medium-sized rings. Rucaparib can be synthesized via this reaction, providing an advantageous synthetic method for the FDA-approved cancer medicine.

A convenient synthesis of 4-substituted 1,2,3,4-tetrahydroisoquinolin-4-ols by a novel intramolecular Barbier reaction and by an insertion reaction: Reaction scope and limitations

4-Substituted 1,2,3,4-tetrahydroisoquinolin-4-ols were prepared from N-(2-iodobenzyl)phenacylamines by an intramolecular Barbier reaction with butyllithium and by an insertion reaction with zerovalent nickel. The scope and limitations of these reactions were discussed.