764680-82-2

Upstream product

• 343308-49-6 methyl 4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoate 
• 343308-52-1 4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoic acid 
• 343308-46-3 methyl 4-(3-bromopropoxy)-3-methoxybenzoate 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 110-85-0 piperazine 
• 343308-55-4 (2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 

Downstream Products

• 871813-96-6 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy 2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] 

Relevant academic research and scientific papers

DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer

New pyrrolobenzodiazepine (PBD) dimers have been developed that are composed of two DC-81 subunits tethered to their C8 positions through piperazine moiety side-armed with alkaneoxy linkers (composed of 2-5 carbons). DNA thermal denaturation studies show

Pyrrolo[2,1-c][1,4] benzodiazepines compounds and process thereof

The present invention provides Analogues of 1,1′-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one] of formula (VI) where n=2 to 10; a pharmaceutical composition comprising the above

PYRROLO[(2,1-C)(1,4) BENZODIAZEPINES DIMERS AS ANTITUMOUR AGENTS AND PROCESS THEREOF

The present invention provides Analogues of 1, 1'-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one] of formula (VI) where n = 2 to 10; a pharmaceutical composition comprising the abo