764717-65-9Relevant academic research and scientific papers
Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor
Osman, Khan T.,Ye, Juntao,Shi, Zhihao,Toker, Christina,Lovato, Diogo,Jumani, Rajiv S.,Zuercher, William,Huston, Christopher D.,Edwards, Aled M.,Lautens, Mark,Santhakumar, Vijayaratnam,Hui, Raymond
, p. 1672 - 1680 (2017)
FIKKs are parasite-specific protein kinases with distinctive sequence motifs and their biological roles have not been completely elucidated. Here, we report the first potent Cryptosporidium FIKK (CpFIKK) inhibitor. We identified 4b as a potent (IC50 = 0.2
Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitors
Gellibert, Fran?oise,Woolven, James,Fouchet, Marie-Hélène,Mathews, Neil,Goodland, Helen,Lovegrove, Victoria,Laroze, Alain,Nguyen, Van-Loc,Sautet, Stéphane,Wang, Ruolan,Janson, Cheryl,Smith, Ward,Krysa, Ga?l,Boullay, Valérie,De Gouville, Anne-Charlotte,Huet, Stéphane,Hartley, David
, p. 4494 - 4506 (2007/10/03)
Optimization of the screening hit 1 led to the identification of novel 1,5-naphthyridine aminothiazole and pyrazole derivatives, which are potent and selective inhibitors of the transforming growth factor-β type I receptor, ALK5. Compounds 15 and 19, whic
