76472-23-6Relevant articles and documents
Synthetic method of hordenine hydrochloride
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Paragraph 0030; 0032; 0033; 0034; 0035; 0036; 0037-0040, (2017/08/30)
The invention discloses a synthetic method of hordenine hydrochloride. According to the synthetic method of hordenine hydrochloride, methyl 4-hydroxyphenylacetate and dimethylamine are taken as raw materials, a protonic solvent and a polar aprotic solvent are taken as solvents so as to obtain N,N-dimethyl-4-hydroxybenzeneacetamide; N,N-dimethyl-4-hydroxybenzeneacetamide is taken as a raw material, tetrahydrofuran is taken as a solvent, and a reducing agent and a catalyst are added so as to obtain hordenine; hydrochloric acid is added, ethanol is taken as a solvent, and hordenine hydrochloride is obtained via reaction. In the synthetic method, methyl 4-hydroxyphenylacetate is taken as a raw material, hordenine hydrochloride is obtained via two-step synthesis, the raw materials are easily available, the synthesis method is simple, amplification production is convenient to realize, production cost is low, industrialized production is convenient to realize, and market potential is high.
OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE
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Page/Page column 30, (2010/04/06)
The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein R1 represents a carbamoyl group; R2 represents a lower alkyl group; both of X1 and X2 represent CH, or any one of X1 and X2 represents a nitrogen atom and the other represents CH; a group of represents a group selected from the group consisting of a pyridinyl, a pyrazinyl, a pyrazolyl, a thiadiazolyl, a triazolyl, an isoxazolyl and a thiazolyl group; and k is zero or 1, or relates to pharmaceutically acceptable salts thereof.