764722-59-0

Basic information

• Product Name: ((R)-1-{(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl)-carbamic acid tert-butyl ester
• CAS NO: 764722-59-0
• Molecular Weight: 560.617
• Mol File: 764722-59-0.mol

Chemical Properties

• CAS DataBase Reference: ((R)-1-{(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((R)-1-{(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl)-carbamic acid tert-butyl ester(764722-59-0)
• EPA Substance Registry System: ((R)-1-{(S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl)-carbamic acid tert-butyl ester(764722-59-0)

Safety Data

• Hazardous Substances Data: 764722-59-0(Hazardous Substances Data)

Upstream product

• 181146-88-3 4'-(trifluoromethyl)-4-biphenylcarbonyl chloride 
• 169749-99-9 (3S)-(-)-1-benzyl-3-(methylamino)pyrrolidine 
• 122536-77-0 3-N-tert-butoxycarbonyl-3-(R)-aminopyrrolidine 
• 762285-67-6 4'-Trifluoromethyl-biphenyl-4-carboxylic acid ((S)-1-benzyl-pyrrolidin-3-yl)-methyl-amide 
• 764722-58-9 3-tert-butoxycarbonylamino-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester 
• 762285-68-7 4'-Trifluoromethyl-biphenyl-4-carboxylic acid methyl-(S)-pyrrolidin-3-yl-amide 

Relevant articles and documents

Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1

The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited potent binding affinity and functional activity at MCH-R1, and good oral bioavailability in rat.