764722-58-9Relevant academic research and scientific papers
Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1
Rowbottom, Martin W.,Vickers, Troy D.,Dyck, Brian,Grey, Jonathan,Tamiya, Junko,Zhang, Mingzhu,Kiankarimi, Mehrak,Wu, Dongpei,Dwight, Wesley,Wade, Warren S.,Schwarz, David,Heise, Christopher E.,Madan, Ajay,Fisher, Andrew,Petroski, Robert,Goodfellow, Val S.
, p. 4450 - 4457 (2006)
The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited potent binding affinity and functional activity at MCH-R1, and good oral bioavailability in rat.
