764723-80-0Relevant articles and documents
QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS
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, (2015/11/18)
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS
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Page/Page column 51, (2013/05/21)
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria
Duveau, Damien Y.,Arce, Pablo M.,Schoenfeld, Robert A.,Raghav, Nidhi,Cortopassi, Gino A.,Hecht, Sidney M.
experimental part, p. 6429 - 6441 (2010/10/03)
Analogues of mitoQ and idebenone were synthesized to define the structural elements that support oxygen consumption in the mitochondrial respiratory chain. Eight analogues were prepared and fully characterized, then evaluated for their ability to support oxygen consumption in the mitochondrial respiratory chain. While oxygen consumption was strongly inhibited by mitoQ analogues 2-4 in a chain length-dependent manner, modification of idebenone by replacement of the quinone methoxy groups by methyl groups (analogues 6-8) reduced, but did not eliminate, oxygen consumption. Idebenone analogues 6-8 also displayed significant cytoprotective properties toward cultured mammalian cells in which glutathione had been depleted by treatment with diethyl maleate.