764723-92-4Relevant academic research and scientific papers
Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria
Duveau, Damien Y.,Arce, Pablo M.,Schoenfeld, Robert A.,Raghav, Nidhi,Cortopassi, Gino A.,Hecht, Sidney M.
experimental part, p. 6429 - 6441 (2010/10/03)
Analogues of mitoQ and idebenone were synthesized to define the structural elements that support oxygen consumption in the mitochondrial respiratory chain. Eight analogues were prepared and fully characterized, then evaluated for their ability to support oxygen consumption in the mitochondrial respiratory chain. While oxygen consumption was strongly inhibited by mitoQ analogues 2-4 in a chain length-dependent manner, modification of idebenone by replacement of the quinone methoxy groups by methyl groups (analogues 6-8) reduced, but did not eliminate, oxygen consumption. Idebenone analogues 6-8 also displayed significant cytoprotective properties toward cultured mammalian cells in which glutathione had been depleted by treatment with diethyl maleate.
MITOQUINONE DERIVATIVES USED AS MITOCHONDRIALLY TARGETED ANTIOXIDANTS
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Page/Page column 60-61, (2010/02/11)
This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds.The exemplified compounds are all mitoquinone derivatives, bei
