76478-30-3

Usage

General Description

2-Acetoxy-5-bromobenzoic acid methyl ester is a chemical compound with the molecular formula C10H9BrO4. It is a derivative of benzoic acid and is commonly used in chemical synthesis and organic reactions. 2-acetoxy-5-bromobenzoic acid methyl ester is a white solid with a melting point of around 90-91 degrees Celsius. It is often used as an intermediate in the production of pharmaceuticals and agrochemicals. The presence of both acetoxy and bromo groups in its structure gives it unique reactivity and makes it useful in a variety of chemical transformations. Note: The information provided is for educational purposes and is not a substitute for professional advice.

Upstream product

• 89-55-4 5-bromosalicyclic acid 
• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 
• 108-24-7 acetic anhydride 

Downstream Products

• 885053-23-6 (E)-2-acetoxy-5-[2-(4-acetoxyphenyl)-vinyl]-benzoic acid methyl ester 

Relevant academic research and scientific papers

Stilbene analogs as inducers of apolipoprotein-I transcription

Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4′-Dihydroxy-2-methoxystilbene was the most potent (4.6× more potent than Resveratrol). These compounds provide an early lead into new drugs to treat atherosclerosis.

STILBENES AND CHALCONES FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES

The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.

Synthesis of fluorovinylsalicylic acids and their derivatives

Palladium-catalyzed cross-coupling of iodosalicylic acid derivatives with polyfluorovinyl zinc reagents provided the corresponding fluorovinyl-substituted salicylates.Methyl-5-(β,β)-difluorovinyl methyl salicylate was prepared by a Wittig reaction of the 5-formyl compound with the strongly nucleophilic ylide, .In one sequence, a fluorine-free benzofuran was obtained, instead of a difluorovinylsalicylate. - Keywords: Fluorovinylsalicylic acids; Wittig reaction; Benzofuran