76478-53-0 Usage
Uses
Used in Pharmaceutical Industry:
(1R,4R)-Bicyclo[2.2.2]octane-2,5-dione is used as a building block for the synthesis of various complex organic molecules and pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs and medicinal compounds.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
(1R,4R)-Bicyclo[2.2.2]octane-2,5-dione is used as a chiral auxiliary in asymmetric synthesis to control the stereochemistry of reactions. This application is crucial for the production of enantiomerically pure compounds, which are essential in many pharmaceutical and chemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 76478-53-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,4,7 and 8 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 76478-53:
(7*7)+(6*6)+(5*4)+(4*7)+(3*8)+(2*5)+(1*3)=170
170 % 10 = 0
So 76478-53-0 is a valid CAS Registry Number.
76478-53-0Relevant academic research and scientific papers
Preparation of C2-symmetric bicyclo[2.2.2]octa-2,5-diene ligands and their use for rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids
Otomaru, Yusuke,Okamoto, Kazuhiro,Shintani, Ryo,Hayashi, Tamio
, p. 2503 - 2508 (2007/10/03)
(Chemical Equation Presented) C2-Symmetric bicyclo[2.2.2]octa-2, 5-dienes containing benzyl, phenyl, and substituted phenyl groups at 2 and 5 positions were prepared enantiomerically pure by way of bicyclo[2.2.2]octane-2, 5-dione as a key intermediate. These chiral diene ligands were successfully applied to rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to α,β-unsaturated ketones. High enantioselectivity (up to 99% ee) as well as high catalytic activity was observed in the addition to both cyclic and linear substrates.
