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2-phenyl-4-(3-trifluoromethyl-benzylidene)-4H-oxazol-5-one is a complex organic compound with a molecular formula of C17H10F3NO2. It features a 4H-oxazol-5-one core structure, which is a heterocyclic ring system containing oxygen and nitrogen atoms. The compound is characterized by a phenyl group attached to the 2-position and a 3-trifluoromethyl-benzylidene group at the 4-position, which contributes to its unique chemical properties. This molecule is of interest in the field of organic chemistry, potentially for its applications in pharmaceuticals or materials science, due to its specific structural features and the presence of electron-withdrawing trifluoromethyl and phenyl groups.

7648-22-8

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7648-22-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7648-22-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,6,4 and 8 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7648-22:
(6*7)+(5*6)+(4*4)+(3*8)+(2*2)+(1*2)=118
118 % 10 = 8
So 7648-22-8 is a valid CAS Registry Number.

7648-22-8Relevant academic research and scientific papers

Synthesis and evaluation of new phenyl acrylamide derivatives as potent non-nucleoside anti-HBV agents

Gu, Xiaoke,Zhang, Yinpeng,Zou, Yueting,Li, Xin,Guan, Mingyu,Zhou, Qingqing,Qiu, Jingying

, (2020/12/09)

As a continuation of our previous work, a series of new phenyl acrylamide derivatives (4Aa-g, 4Ba-t, 5 and 6a-c) were designed and synthesized as non-nucleoside anti-HBV agents. Among them, compound 4Bs could potently inhibit HBV DNA replication in wild-type and lamivudine (3TC)/entecavir resistant HBV mutant strains with IC50 values of 0.19 and 0.18 μM, respectively. Notably, the selective index value of 4Bs was above 526, indicating the favorable safety profile. Interestingly, unlike nucleoside analogue 3TC, 4Bs could significantly inhibit 3.5 kb pgRNA expression. Molecular docking study revealed that 4Bs could fit well into the dimer-dimer interface of HBV core protein by hydrophobic, π–π and H-bond interactions. Considering the potent anti-HBV activity, low toxicity and diverse anti-HBV mechanism from that of nucleoside anti-HBV agent 3TC, compound 4Bs might be a promising lead to develop novel non-nucleoside anti-HBV therapeutic agents, and warranted further investigation.

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