76492-19-8Relevant academic research and scientific papers
Engineered transaminopeptidase, aminolysin-S for catalysis of peptide bond formation to give linear and cyclic dipeptides by one-pot reaction
Usuki, Hirokazu,Uesugi, Yoshiko,Arima, Jiro,Yamamoto, Yukihiro,Iwabuchi, Masaki,Hatanaka, Tadashi
supporting information; experimental part, p. 580 - 582 (2010/05/01)
Aminopeptidase from Streptomyces thermocyaneoviolaceus NBRC14271 was engineered into transaminopeptidase and used to catalyze an aminolysis reaction to give linear and cyclic dipeptides from cost-effective substrates such as the ester derivatives of amino
Mechanism study on the oligomerization of amino acids into peptides by phosphorus trichloride
Zhao, Wenjie,Zhao, Dongxin,Lu, Kui
scheme or table, p. 691 - 698 (2009/05/07)
As treated by phosphorus trichloride, amino acids could oligomerize into polypeptides. Based on the results obtained by 31P-NMR and ESI-MS/MS, a possible reaction mechanism was proposed. The mechanism might undergo a penta-coordinated phosphorus intermediat. The activated amino acid was a five-membered cyclic penta-coordinated phosphorus intermediate. The nucleophilic attack of the amino group from an amino acid or peptide on the carbonyl group of intermediate led to the formation of peptide and released one equivalent dichloride phosphoric acid. The repetition of the reaction sequence generated a series of oligopeptides. Copyright Taylor & Francis Group, LLC.
