76507-16-9Relevant academic research and scientific papers
Method for inhibiting advanced glycosylation of proteins using aminosubstituted imidazoles
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, (2008/06/13)
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging), Accordingly, a composition is disclosed which comprises 2-aminoimidazoles capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation, The method comprises contacting the target protein with the composition, Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
Synthesis and Halogenation of Some New 2-Amino-4-substituted Iminazoles and Their Possible Use as Pesticides
Nath, J. P.,Mahapatra, G. N.
, p. 526 - 528 (2007/10/02)
2-Amino-4-substituted iminazoles (1a-k) have been synthesised by condensing various ketones with guanidine using bromine as condensing agent in dry methanol.These have been halogenated to yield the corresponding 5-halogeno derivatives (II, III).Both halogenated and nonhalogenated iminazoles exhibit antifungal activity against Piricularia oryzae (Cav.) and antibacterial activity against the common pathogenic bacteria, Staphy. aureus and Esch. coli.Structure-activity relationship has also been discussed.
