7651-47-0

Basic information

• Product Name: 4'-CHLOROACETOPHENONETHIOSEMICARBAZONE
• Synonyms: 4'-CHLOROACETOPHENONETHIOSEMICARBAZONE;p-Chloroacetophenone thiosemicarbazone
• CAS NO: 7651-47-0
• Molecular Formula: C₉H₁₀ClN₃S
• Molecular Weight: 227.7138
• Mol File: 7651-47-0.mol

Chemical Properties

• Boiling Point: 349°Cat760mmHg
• Flash Point: 164.9°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 4.84E-05mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 4'-CHLOROACETOPHENONETHIOSEMICARBAZONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-CHLOROACETOPHENONETHIOSEMICARBAZONE(7651-47-0)
• EPA Substance Registry System: 4'-CHLOROACETOPHENONETHIOSEMICARBAZONE(7651-47-0)

Safety Data

• Hazardous Substances Data: 7651-47-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H10ClN3S/c1-6(12-13-9(11)14)7-2-4-8(10)5-3-7/h2-5H,1H3,(H3,11,13,14)/b12-6+

Upstream product

• 99-91-2 para-chloroacetophenone 
• 79-19-6 thiosemicarbazide 
• 4346-94-5 thiosemicarbazide hydrochloride 

Downstream Products

• 36937-62-9 1-(4-chloro-phenyl)-ethanone (4-thiophen-2-yl-thiazol-2-yl)-hydrazone 
• 36937-57-2 1-(4-chloro-phenyl)-ethanone [4-(4-chloro-phenyl)-thiazol-2-yl]-hydrazone 
• 36937-61-8 1-(4-chloro-phenyl)-ethanone (4-naphthalen-2-yl-thiazol-2-yl)-hydrazone 
• 80412-54-0 C₁₆H₁₆ClN₅S*ClH 
• 80412-55-1 C₁₇H₁₈ClN₅S*ClH 
• 80412-56-2 C₁₆H₁₅Cl₂N₅S*ClH 
• 80412-57-3 C₁₈H₂₀ClN₅OS*ClH 
• 99-91-2 para-chloroacetophenone 
• 244104-87-8 3-(2-{N'-[1-(4-chloro-phenyl)-ethylidene]-hydrazino}-thiazol-4-yl)-8-methoxy-chromen-2-one 
• 80412-73-3 (5-{N'-[1-(4-Chloro-phenyl)-eth-(E)-ylidene]-hydrazino}-[1,2,4]thiadiazol-3-yl)-phenyl-amine 
• 80412-74-4 (5-{N'-[1-(4-Chloro-phenyl)-eth-(E)-ylidene]-hydrazino}-[1,2,4]thiadiazol-3-yl)-p-tolyl-amine 
• 80412-75-5 (4-Chloro-phenyl)-(5-{N'-[1-(4-chloro-phenyl)-eth-(E)-ylidene]-hydrazino}-[1,2,4]thiadiazol-3-yl)-amine 
• 80412-76-6 (5-{N'-[1-(4-Chloro-phenyl)-eth-(E)-ylidene]-hydrazino}-[1,2,4]thiadiazol-3-yl)-(4-ethoxy-phenyl)-amine 
• 121922-85-8 Cu⁽¹⁺⁾*C₉H₉ClN₃S^(1-)={Cu(C₆H₄ClC(CH₃)NNCSNH₂)} 

Relevant articles and documents

Eco-friendly sequential one-pot synthesis, molecular docking, and anticancer evaluation of arylidene-hydrazinyl-thiazole derivatives as CDK2 inhibitors

One current approach in the treatment of cancer is the inhibition of cyclin dependent kinase (CDK) enzymes with small molecules. CDK are a class of enzymes, which catalyze the transfer of the terminal phosphate of a molecule of ATP to a protein that acts

Design, synthesis and molecular docking studies of some thiazole clubbed heterocyclic compounds as possible anti-infective agents

The present work describes synthesis of a series of 5-((1-(4-(4-chlorophenyl)thiazol-2-yl)-3- aryl-1H-pyrazol-4-yl)methylene)-2-(arylimino)thiazolidin-4-one derivatives and their molecular docking and biological evaluation as possible antimalarial, anthelmintic and antimicrobial agents. The synthesis of compounds has been accomplished by adopting suitable synthetic methods. Structures of newly synthesized compounds were characterized and authenticated by spectral methods such as IR, 1H-NMR and mass spectra. Synthesized compounds were screened for their in vitro antimicrobial activity against selected bacterial strains and fungal strains viz. B. subtilis, S. aureus, E. coli, P. fluorescens, C. albicans, C. glabrata and antimalarial studies against P. falciparum. Titled compounds were also tested against Pheretima posthuma (earthworm) for their anthelmintic activity. Molecular docking was done to study the binding modes of the potent compounds against Escherichia coli (PDB ID: 1AB4) and Candida P450DM (PDB ID: 1EA1) enzymes. The results revealed that all the compounds exhibited moderate to significant antimicrobial activities. Antimalarial activity screening revealed that one compound 8i showed significant antimalarial activity with of IC50; 0.59 μg/mL as compared to standard drugs chloroquine (IC50= 0.020 μg/mL) and quinine (IC50; 0.268 μg/mL). The most active compound exhibited the mean paralysis time of 19.2 ± 0.9 min and mean death time of 31.7 ± 2.5 min. It can be concluded that some of the synthesized compounds have remarkable antiinfective, antimalarial and anthelmintic activity and are suitable candidates for further scientific exploration.

Structure-activity relationship study of thiosemicarbazones on an African trypanosome: Trypanosoma brucei brucei

To explore the structure-activity relationships of thiosemicarbazones on African trypanosome: Trypanosoma brucei brucei, a series of thirty-five thiosemicarbazones (1-35) have been synthesized and characterized by their 1H NMR, 13C NMR, and FT-IR spectra. All compounds were tested for trypanocidal activity using the method "Lilit alamar blue". The comparison of trypanocidal power of thiosemicarbazones was performed considering their structures. This study that was done using acetophenone thiosemicarbazone (1) as basic model, showed that: (a) the presence of lipophilic substituents in para position on benzene ring, (b) substitution of benzene ring and (c) substitution of hydrogen of thioamide function by a phenyl, strongly influence trypanocidal activity. The various modifications to basic structure (1) allowed the synthesis of 1-(4-chlorophenyl) ethylidene-4-phenyl- thiosemicarbazide (34). With a trypanocidal activity of 3.97 μM, this compound is the most active of the series.

Ruthenium(II) mediated C-H activation of substituted acetophenone thiosemicarbazones: Synthesis, structural characterization, luminescence and electrochemical properties

Treatment of [RuHCl(CO)(AsPh3)3] with 4′-substituted acetophenone thiosemicarbazone derivatives in methanol under reflux afford a series of air stable new ruthenium(II) cyclometalated complexes containing thiosemicarbazone of general

M-STAGE KINESIN INHIBITOR

A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom, -C(=W)R6 (wherein W represents an oxygen atom or a sulfur atom, and R6 represents substituted or unsubstituted lower alkyl and the like) and the like, R3 represents -C(=Z)R19 (wherein Z represents an oxygen atom or a sulfur atom, and R19 represents substituted or unsubstituted lower alkyl and the like) and the like, R4 represents substituted or unsubstituted lower alkyl and the like, and R5 represents substituted or unsubstituted aryl and the like] and the like are provided.

THIADIAZOLINE DERIVATIVE

(wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R2 represents -C(-W)R6 or the like; R3 represents a hydrogen atom, -C(=WA)R6A, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.

Synthesis, oxidation and dehydrogenation of cyclic N,O- and N,S-acetals. Part 1. Transformation of N,S-acetals: 3-acyl-1,3,4-thiadiazolines

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