7651-47-0

Basic information

• Product Name: 4'-CHLOROACETOPHENONETHIOSEMICARBAZONE
• Synonyms: 4'-CHLOROACETOPHENONETHIOSEMICARBAZONE;p-Chloroacetophenone thiosemicarbazone
• CAS NO: 7651-47-0
• Molecular Formula: C₉H₁₀ClN₃S
• Molecular Weight: 227.7138
• Mol File: 7651-47-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 349°Cat760mmHg
• Flash Point: 164.9°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 4.84E-05mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 4'-CHLOROACETOPHENONETHIOSEMICARBAZONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-CHLOROACETOPHENONETHIOSEMICARBAZONE(7651-47-0)
• EPA Substance Registry System: 4'-CHLOROACETOPHENONETHIOSEMICARBAZONE(7651-47-0)

Safety Data

• Hazardous Substances Data: 7651-47-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H10ClN3S/c1-6(12-13-9(11)14)7-2-4-8(10)5-3-7/h2-5H,1H3,(H3,11,13,14)/b12-6+

Upstream product

• 4346-94-5 thiosemicarbazide hydrochloride 
• 99-91-2 para-chloroacetophenone 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 121922-85-8 Cu⁽¹⁺⁾*C₉H₉ClN₃S^(1-)={Cu(C₆H₄ClC(CH₃)NNCSNH₂)} 
• 1516632-28-2 1-(1-p-chlorophenyl)ethylidene-2-[4-(5-methyl-1-p-tolyl-1,2,3-triazol-4-yl)thiazol-2-yl]hydrazine 
• 80412-76-6 (5-{N'-[1-(4-Chloro-phenyl)-eth-(E)-ylidene]-hydrazino}-[1,2,4]thiadiazol-3-yl)-(4-ethoxy-phenyl)-amine 
• 80412-75-5 (4-Chloro-phenyl)-(5-{N'-[1-(4-chloro-phenyl)-eth-(E)-ylidene]-hydrazino}-[1,2,4]thiadiazol-3-yl)-amine 
• 80412-74-4 (5-{N'-[1-(4-Chloro-phenyl)-eth-(E)-ylidene]-hydrazino}-[1,2,4]thiadiazol-3-yl)-p-tolyl-amine 
• 80412-73-3 (5-{N'-[1-(4-Chloro-phenyl)-eth-(E)-ylidene]-hydrazino}-[1,2,4]thiadiazol-3-yl)-phenyl-amine 
• 244104-87-8 3-(2-{N'-[1-(4-chloro-phenyl)-ethylidene]-hydrazino}-thiazol-4-yl)-8-methoxy-chromen-2-one 

Relevant articles and documents

Eco-friendly sequential one-pot synthesis, molecular docking, and anticancer evaluation of arylidene-hydrazinyl-thiazole derivatives as CDK2 inhibitors

One current approach in the treatment of cancer is the inhibition of cyclin dependent kinase (CDK) enzymes with small molecules. CDK are a class of enzymes, which catalyze the transfer of the terminal phosphate of a molecule of ATP to a protein that acts

Structure-activity relationship study of thiosemicarbazones on an African trypanosome: Trypanosoma brucei brucei

To explore the structure-activity relationships of thiosemicarbazones on African trypanosome: Trypanosoma brucei brucei, a series of thirty-five thiosemicarbazones (1-35) have been synthesized and characterized by their 1H NMR, 13C NMR, and FT-IR spectra. All compounds were tested for trypanocidal activity using the method "Lilit alamar blue". The comparison of trypanocidal power of thiosemicarbazones was performed considering their structures. This study that was done using acetophenone thiosemicarbazone (1) as basic model, showed that: (a) the presence of lipophilic substituents in para position on benzene ring, (b) substitution of benzene ring and (c) substitution of hydrogen of thioamide function by a phenyl, strongly influence trypanocidal activity. The various modifications to basic structure (1) allowed the synthesis of 1-(4-chlorophenyl) ethylidene-4-phenyl- thiosemicarbazide (34). With a trypanocidal activity of 3.97 μM, this compound is the most active of the series.

M-STAGE KINESIN INHIBITOR

A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom, -C(=W)R6 (wherein W represents an oxygen atom or a sulfur atom, and R6 represents substituted or unsubstituted lower alkyl and the like) and the like, R3 represents -C(=Z)R19 (wherein Z represents an oxygen atom or a sulfur atom, and R19 represents substituted or unsubstituted lower alkyl and the like) and the like, R4 represents substituted or unsubstituted lower alkyl and the like, and R5 represents substituted or unsubstituted aryl and the like] and the like are provided.