76514-48-2

Basic information

• Product Name: N-Tosyl-S-tert-butyl-L-cysteine Methyl Ester
• Synonyms: N-Tosyl-S-tert-butyl-L-cysteine Methyl Ester
• CAS NO: 76514-48-2
• Molecular Weight: 345.484
• Mol File: 76514-48-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Tosyl-S-tert-butyl-L-cysteine Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Tosyl-S-tert-butyl-L-cysteine Methyl Ester(76514-48-2)
• EPA Substance Registry System: N-Tosyl-S-tert-butyl-L-cysteine Methyl Ester(76514-48-2)

Safety Data

• Hazardous Substances Data: 76514-48-2(Hazardous Substances Data)

Upstream product

• 2481-09-6 S-tert-Butyl-N-acetyl-L-cysteine hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 67-56-1 methanol 
• 65798-32-5 N-Tosyl-S-tert-butyl-L-cysteine 

Downstream Products

• 76499-07-5 N-Tosyl-S-tert-butyl-L-cysteine Hydrazide 

Relevant articles and documents

tert-Butyl group as thiol protection in peptide synthesis

S-tert-Butylcysteine was obtained by a new method. A number of its N-protected derivatives and esters were synthesized. Syntheses of several peptides containing tert-butyl and acetamidomethyl or benzyl thioethers of cysteine were carried out. The tert-butyl group was removed from the thiol group of peptides by treatment with (2-nitrophenyl)sulfenyl chloride (NpsCl). The S-(2-nitrophenyl)sulfenyl derivatives so obtained were converted either into cysteine by reduction or into cystine derivatives by disproportionation. Owing to the mild deprotection conditions and the great stability of the S-tert-butyl group, the other protecting groups, particularly those of the thiols, could be easily removed from a variety of combinations.