76520-52-0

Upstream product

• 127135-76-6 (E)-(S)-6-[(1R,3R,3aR,3bS,6R,6aR,6bR)-3-(4-Methoxy-benzyloxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-methyl-hepta-3,6-diene-2,5-diol 
• 132101-60-1 tert-Butyl-{2-[(1R,3R,3aR,3bS,6R,6aR,6bR)-3-(4-methoxy-benzyloxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-allyloxy}-dimethyl-silane 
• 127135-71-1 (E)-(S)-6-[(1R,3R,3aR,3bS,6R,6aR,6bR)-3-(4-Methoxy-benzyloxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-methyl-5-triethylsilanyloxy-hepta-3,6-dien-2-ol 
• 127135-69-7 C₁₁H₂₃LiOSi 
• 127135-70-0 (E)-(S)-2-[(1R,3R,3aR,3bS,6R,6aR,6bR)-3-(4-Methoxy-benzyloxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-6-methyl-6-triethylsilanyloxy-hepta-1,4-dien-3-ol 
• 127135-72-2 (R)-1-[(2S,3R)-3-(1-Hydroxy-1-methyl-ethyl)-oxiranyl]-2-[(1R,3R,3aR,3bS,6R,6aR,6bR)-3-(4-methoxy-benzyloxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-prop-2-en-1-ol 
• 127135-74-4 Methanesulfonic acid (R)-1-[(2R,3R)-3-(1-hydroxy-1-methyl-ethyl)-oxiranyl]-2-[(1R,3R,3aR,3bS,6R,6aR,6bR)-3-(4-methoxy-benzyloxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-allyl ester 
• 127156-24-5 2-[(1R,3R,3aR,3bS,6R,6aR,6bR)-3-(4-Methoxy-benzyloxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-propenal 
• 105453-22-3 (R)-3,3-dimethyloxirane-2-carboxaldehyde 
• 127135-75-5 (2S,2'S,3'S)-3'-{1-[(1R,3R,3aR,3bS,6R,6aR,6bR)-3-(4-Methoxy-benzyloxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-vinyl}-3,3-dimethyl-[2,2']bioxiranyl 
• 127182-31-4 (R)-1-[(2R,3S)-3-(1-Hydroxy-1-methyl-ethyl)-oxiranyl]-2-[(1R,3R,3aR,3bS,6R,6aR,6bR)-3-(4-methoxy-benzyloxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-prop-2-en-1-ol 
• 127182-28-9 (1R,3R,3aR,3bR,4R,6aS,6bR)-3-(1-Hydroxymethyl-vinyl)-4,6b-dimethyl-decahydro-cyclobutadicyclopenten-1-ol 
• 132101-61-2 2-[(1R,3R,3aR,3bS,6R,6aR,6bR)-3-(4-Methoxy-benzyloxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-prop-2-en-1-ol 
• 132101-59-8 (1R,3R,3aR,3bR,4R,6aS,6bR)-3-[1-(tert-Butyl-dimethyl-silanyloxymethyl)-vinyl]-4,6b-dimethyl-decahydro-cyclobutadicyclopenten-1-ol 

Downstream Products

• 86887-31-2 4-Bromo-benzoic acid (1R,3R,3aR,3bR,4R,6aS,6bR)-3-{1-[(2S,3S)-3-((R)-1-chloro-2-hydroxy-2-methyl-propyl)-oxiranyl]-vinyl}-4,6b-dimethyl-decahydro-cyclobutadicyclopenten-1-yl ester 

Relevant academic research and scientific papers

Total Synthesis of Natural (+)-Spatol. Confirmation of The Absolute Stereostructure

Total synthesis of optically pure spatol (+)-1 was achieved by employing asymmetric (2+2) photocycloaddition of the optically pure 12 with cyclopentenone ethylene ketal.The two major photocycloadducts 14, 15 were separately converted into the cis,anti,cis-tricyclo2,6>decane 9 and then to the sulfonium 11.Coupling of 11 through ylide with optically active epoxyaldehyde 24 provided optically pure 1 with definite absolute configuration.

TOTAL SYNTHESIS OF (+)-SPATOL. A STEREOSPECIFIC CONSTRUCTION OF VICINAL DIEPOXIDES FROM 2,3-EPOXY-1,4-DIOLS

A total synthesis of (+)-spatol (1) was achived which depends upon a novel stereospecific transformation of trans-2,3-epoxy-1,4-diols to generate sensitive allylic vicinal cis-epoxide in 1.