76527-89-4Relevant academic research and scientific papers
Synthesis and carcinogenic activity of oxidized benzacridines: Potential metabolites of the strong carcinogen 7-methylbenz[c]acridine and of the inactive isomer 12-methylbenz[a]acridine
Croisy Delcey,Croisy,Zajdela,Lhoste
, p. 303 - 306 (2007/10/02)
The synthesis of 15 compounds related either to the benz[c]acridine or to the benz[a]acridine series is reported. Spectral data, i.e., NMR and EI fragmentation are given. These compounds were tested for carcinogenic activity in mice of the XVIInc/Z strain by subcutaneous injection. Only three weak carcinogens were detected 5,6-dihydro-5,6-dihydroxy-12-methylbenz[a]acridine, 3-methoxy 7-methylbenz[c]acridine, and 4-acetoxy-7-methylbenz[c]acridine. These results are discussed with consideration to the data previously obtained with other benzacridines and condensed quinolines.
POTENTIAL METABOLITES OF CARCINOGENIC AZA AROMATIC HYDROCARBONS. SYNTHESIS OF K-REGION OXIDE, PHENOL AND DIHYDRODIOLS OF 7-METHYLBENZACRIDINE
Boux, L. J.,Cheung, H. T. A.,Holder, G. M.,Moldovan, L.
, p. 2923 - 2926 (2007/10/02)
The potential K-region metabolites, trans- and cis-5,6-dihydroxy-7-methyl-5,6-dihydrobenzacridine, 5,6-epoxy-7-methyl-5,6-dihydrobenzacridine and 5-hydroxy-7-methylbenzacridine, of 7-methylbenzacridine have been synthesized.
