3340-94-1

Usage

InChI:InChI=1/C18H13N/c1-12-14-7-4-5-9-17(14)19-18-15(12)11-10-13-6-2-3-8-16(13)18/h2-11H,1H3

Upstream product

• 102184-25-8 benz[c]acridin-7-yl-malononitrile 
• 90-30-2 N-phenyl-1-naphthylamine 
• 64-19-7 acetic acid 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 86538-47-8 1,2,3,4-tetrahydro-7-methylbenzacridine 
• 551-93-9 2-aminoacetophenone 
• 102940-92-1 7-chlorobenzacridine 
• 13922-41-3 1-Naphthylboronic acid 
• 90-11-9 1-Bromonaphthalene 
• 104014-45-1 1-<2-(1-Naphthylamino)phenyl>ethanon 
• 420132-02-1 di-(1-naphthalenyl)iodonium triflate 

Downstream Products

• 63021-48-7 7-(3-nitro-trans-styryl)-benz[c]acridine 
• 63019-60-3 9-(4-Dimethylamino-styryl)-1,2-benzacridin 
• 34331-99-2 7-bromomethyl-benzo[c]acridine 
• 107146-22-5 trans-6-hydroxy-5-methoxy-7-methyl-5,6-dihydrobenzacridine 
• 107146-23-6 trans-5-hydroxy-6-methoxy-7-methyl-5,6-dihydrobenzoacridine 
• 76527-87-2 5,6-epoxy-7-methyl-5,6-dihydrobenzacridine 
• 78167-98-3 (1aS,11bR)-1a,11b-Dihydro-1-oxa-6-aza-benzo[a]cyclopropa[c]anthracene 
• 76527-89-4 cis-5,6-dihydroxy-7-methyl-5,6-dihydrobenzacridine 
• 76527-88-3 trans-5,6-dihydroxy-7-methyl-5,6-dihydrobenzacridine 
• 102024-10-2 acetic acid benz[c]acridin-7-ylmethyl ester 
• 73566-39-9 7-Hydroxymethylbenzacridin 
• 76527-92-9 5-hydroxy-7-methylbenzacridine 

Relevant academic research and scientific papers

Synthesis of Acridines from o-Aminoaryl Ketones and Arylboronic Acids by Copper Trifluoroacetate-Mediated Relay Reactions

An efficient and practical method for the synthesis of medicinally important acridines from readily available o-aminoaryl ketones and arylboronic acids was developed using copper(II)-mediated relay reactions that involve intermolecular Chan-Lam cross-coupling and subsequent intramolecular Friedel-Crafts-type reactions. A sole promoter, i.e., Cu(OTf)2, was used; therefore, strongly acidic and basic conditions, nonreadily available or expensive substrates, additives, and noble-metal catalysts were not needed.

Tandem arylation/friedel-crafts reactions of o-acylanilines with diaryliodonium salts: A modular synthesis of acridine derivatives

A modular method to synthesize acridine derivatives was developed with o-acylanilines and diaryliodonium salts. The reactions proceeded smoothly under Cu-catalyzed or metal-free reaction conditions at elevated temperature through tandem arylation/Friedel-Crafts reactions.

Rapid synthesis of acridines using microwave

Microwave irradiation for several minutes caused reaction of diarylamines with carboxylic acids in the presence of zinc chloride to give 9-substituted acridines in good yield.

Synthesis of the Non-K-Region Dihydrodiols of 7-Methylbenzacridine

The synthesis of the four non-K-region trans-dihydrodiols of 7-methylbenzacridine (2) are described.The trans-8,9- and -10,11-dihydrodiols 13 and 16 were prepared from 7-methyl-8,9,10,11-tetrahydrobenzacridine (3) via the trans-8,9-diacetoxy-7-methyl-8,9,10,11-tetrahydrobenzacridine (10) and its 10,11-isomer (14) by selective benzylic bromination followed by dehydrobromination.The trans-tetrahydro diacetates were obtained through the alkenes 6 and 7 and their epoxide derivatives. trans-1,2- and -3,4-dihydrodiols 22 and 24 were similarly prepared from the trans-1,2- and -3,4-diacetates of 7-methyl-1,2,3,4-tetrahydrobenzacridine (19 and 20).The latter were products of the Prevost reaction on mixed 3,4- and 1,2-dihydro-7-methylbenzacridines (17 and 18).