765274-13-3

Upstream product

• 765274-12-2 pent-4-enyl 6-O-{(2-O-benzoyl-3-O-benzyl-5-O-tert-butyldiphenylsilyl-α-D-arabinofuranosyl)-(1->5)-O-(2-O-benzoyl-3-O-benzyl-α-D-arabinofuranosyl)}-2-O-benzoyl-3-O-benzyl-α-D-arabinofuranoside 
• 100-39-0 benzyl bromide 
• 1255529-68-0 pent-4-enyl 5-O-(5-O-(2-O-benzoyl-3-O-benzyl-5-O-triisopropysilyl-α-D-arabinofuranosyl)-2-O-benzoyl-3-O-benzyl-α-D-arabinofuranosyl)-2-O-benzoyl-3-O-benzyl-α-D-arabinofuranoside 
• 765274-09-7 pent-4-enyl 2-O-benzoyl-3-O-benzyl-α-D-arabinofuranoside 
• 765274-02-0 β-D-arabinofuranose 1,2-(pent-4-enyl orthobenzoate) 
• 821-09-0 n-Pent-4-enyl alcohol 
• 4348-68-9 2,3,5-tri-O-benzoyl-α-D-arabinofuranosyl bromide 
• 765274-10-0 pent-4-enyl 6-O-(2-O-benzoyl-3-O-benzyl-5-O-tert-butyldiphenylsilyl-α-D-arabinofuranosyl)-2-O-benzoyl-3-O-benzyl-α-D-arabinofuranoside 
• 765274-11-1 pent-4-enyl 6-O-(2-O-benzoyl-3-O-benzyl-α-D-arabinofuranosyl)-2-O-benzoyl-3-O-benzyl-α-D-arabinofuranoside 
• 765274-08-6 pent-4-enyl 2-O-benzoyl-3-O-benzyl-5-O-tert-butyldiphenylsilyl-α-D-arabinofuranoside 
• 765274-04-2 3-O-benzyl-5-O-tert-butyldiphenylsilyl-β-D-arabinofuranose 1,2-(pent-4-enyl orthobenzoate) 

Downstream Products

• 1255529-69-1 pent-4-enyl 5-O-(5-O-(5-O-(2-O-benzoyl-3-O-benzyl-5-O-triisopropysilyl-α-D-arabinofuranosyl)-2-O-benzoyl-3-O-benzyl-α-D-arabinofuranosyl)-2-O-benzoyl-3-O-benzyl-α-D-arabinofuranosyl)-2-O-benzoyl-3-O-benzyl-α-D-arabinofuranoside 

Relevant academic research and scientific papers

Development of a plate-based scintillation proximity assay for the mycobacterial AftB enzyme involved in cell wall arabinan biosynthesis

A number of mycobacterial arabinosyltransferases, such as the Emb proteins, AftA, AftB, AftC, and AftD have been characterized and implicated to be involved in the cell wall arabinan assembly. These arabinosyltransferases are essential for the viability of the organism and are logically valid targets for developing new anti-tuberculosis agents. For instance, Ethambutol, a first line anti-tuberculosis drug, targets the Emb proteins involved in the formation of the arabinan of cell wall arabinogalactan. Among these arabinosyltransferases, the terminal β-(1→2) arabinosyltransferase activity has been associated with AftB. The predicted topology of AftB in Mycobacterium tuberculosis has 10 N terminal transmembrane domains and a C terminal hydrophilic domain similar to the Emb proteins. It has a conserved GT-C motif and is difficult to express. In a cell free assay, synthetic disaccharide, α-d-Araf-(1→5)-α-d-Araf-octyl, has been used as a substrate to explore the function of AftB. In our work, the disaccharide was synthesized in its pentenylated and biotinylated form, and the enzymatic product formed was identified as the β-(1→2) arabinofuranose adduct. When synthetic tri-and tetra-saccharides were used as substrates, a mixture of products containing both β-(1→2) and α-(1→5) linkages were formed. Therefore, the biotinylated disaccharide was selected to develop a scintillation proximity assay.

SYNTHESIS OF MONOVALENT AND POLYVALENT ARABINANS AND MANNOSE-CAPPED ARABINANS OF THE PROTECTIVE CELL-WALL COAT OF MYCOBACTERIUM TUBERCULOSIS

The present application provides arabinans and mannose-capped arabinan compositions of formulas I-VIII, described herein, and methods of making the compositions.

Preparation, properties, and applications of n-pentenyl arabinofuranosyl donors

(Chemical Equation Presented) The development of n-pentenyl furanosyl donors has been tested using arabinose as a model. The readily prepared ortho ester (NPOE) is converted into disarmed (NPGAC) and thence armed (NPGALK) n-pentenyl