76535-03-0

Upstream product

• 536-90-3 m-Anisidine 
• 14422-49-2 2-chloroacetamidobenzoic acid 
• 98592-35-9 2-(chloromethyl)-4H-benzo[d][1,3]oxazin-4-one 
• 118-92-3 anthranilic acid 

Downstream Products

• 952614-22-1 2-[4-(4-methanesulphonylphenyl)-5-(morpholin-4-yl)thiophen-2-yl]-3-(3-methoxyphenyl)-3H-quinazolin-4-one 
• 1250276-76-6 C₂₆H₂₆N₄O₄S 
• 1250276-66-4 C₂₁H₂₄N₄O₄S 
• 1190370-11-6 C₂₅H₃₀N₄O₄ 
• 1190370-15-0 C₂₀H₂₂N₄O₂ 
• 80095-96-1 1-<3,4-Dihydro-3-(3-methoxyphenyl)-4-oxo-2-chinazolinylmethyl>-1H-1,2,3-triazol-4,5-dicarbonsaeuredimethylester 
• 81541-39-1 R,S-Essigsaeure(acetamido-<3,4-dihydro-3-<3-methoxyphenyl>-4-oxo-2-chinazolinyl>-methyl)ester 
• 81557-46-2 R,S-N-(<3,4-Dihydro-3-<3-methoxyphenyl>-4-oxo-2-chinazolinyl>-hydroxymethyl)acetamid 
• 345228-23-1 2-Aminomethyl-3,4-dihydro-3-(3-methoxyphenyl)-4-chinazolinon 
• 80096-29-3 2-Azidomethyl-3,4-dihydro-3-(3-methoxyphenyl)-4-chinazolinon 

Relevant academic research and scientific papers

Novel 2,4- thiazolidinediones: Synthesis, in?vitro cytotoxic activity, and mechanistic investigation

Two thiazolidinedione scaffolds different in the position of the thiazolidinedione ring in the molecule were tested for in?vitro cytotoxic activity in a panel of human cancer cell lines namely, prostate cancer cells PC-3, breast carcinoma cells MDA-MB-231

Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-k{cyrillic}B and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer ag

In an attempt to discover novel inhibitors of NF-κB and AP-1 mediated transcriptional activation utilizing the concept of chemical lead based medicinal chemistry and bioisosterism a series of 2-(2,3-disubstituted-thiophen-5-yl)-3H-quinazolin-4-one analogs

Synthesis of novel new 2-(2-(4-((3,4-dihydro-4-oxo-3-aryl quinazolin-2-yl)methyl)piperazin-1-yl)acetoyloxy)-2-phenyl acetic acid esters

Stereoselective diazotization of (S)-2-amino-2-phenyl acetic acid (L-phenyl glycine) (4) with NaNO2 in 6% H2SO4 in a mixture of acetone and water gave optically pure (S)-2-hydroxy-2-phenyl acetic acid (L-mandelic acid) (5). Esterification, gave (S)-2-hydroxy-2-phenyl acetic acid esters (6). The latter was treated with chloroacetyl chloride in the presence of triethylamine (TEA) in dichloromethane (DCM) to yield (S)-2-chloroacetyloxy phenyl acetic acid ester (2). In another sequence, the reaction of 2-(chloromethyl)-3-arylquinazolin- 4(3H)-one (9) treated with N-Boc piperazine, followed by deprotection of the Boc group, to obtain 3-aryl-2-((piperazin-1-yl)methyl) quinazolin-4(3H)-one (3). Reaction of 2 with 3 in the presence of K2CO3 and KI gave the title compound, 2-(2-(4-((3,4-dihydro-4-oxo-3-arylquinazolin-2-yl)methyl)piperazin-1-yl) acetoyloxy)-2-phenyl acetic acid esters (1). The structures of all the new compounds obtained in the present work are supported by spectral and analytical data. Copyright Taylor & Francis Group, LLC.

THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS

Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.

Quinazolinones, 2. Syntheses and Some Reactions of 2-Azido-methyl-3-aryl-4-quinazolinones

Starting with the chloromethyl compounds 7 the new 2-azidomethyl-3-aryl-4-quinazolinones 8a-h were prepared, some of which have been reduced so far to the corresponding amines 9a, b, e, g by H2S in good yield.As a first example for the capability of the a