76535-03-0

Basic information

• Product Name: 2-Chlormethyl-3,4-dihydro-3-(3-methoxyphenyl)-4-chinazolinon
• Synonyms: 2-Chlormethyl-3,4-dihydro-3-(3-methoxyphenyl)-4-chinazolinon
• CAS NO: 76535-03-0
• Molecular Weight: 300.744
• Mol File: 76535-03-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Chlormethyl-3,4-dihydro-3-(3-methoxyphenyl)-4-chinazolinon(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chlormethyl-3,4-dihydro-3-(3-methoxyphenyl)-4-chinazolinon(76535-03-0)
• EPA Substance Registry System: 2-Chlormethyl-3,4-dihydro-3-(3-methoxyphenyl)-4-chinazolinon(76535-03-0)

Safety Data

• Hazardous Substances Data: 76535-03-0(Hazardous Substances Data)

Upstream product

• 118-92-3 anthranilic acid 
• 536-90-3 m-Anisidine 
• 98592-35-9 2-(chloromethyl)-4H-benzo[d][1,3]oxazin-4-one 
• 14422-49-2 2-chloroacetamidobenzoic acid 

Downstream Products

• 1190370-15-0 C₂₀H₂₂N₄O₂ 
• 1190370-11-6 C₂₅H₃₀N₄O₄ 
• 1250276-66-4 C₂₁H₂₄N₄O₄S 
• 1250276-76-6 C₂₆H₂₆N₄O₄S 
• 952614-22-1 2-[4-(4-methanesulphonylphenyl)-5-(morpholin-4-yl)thiophen-2-yl]-3-(3-methoxyphenyl)-3H-quinazolin-4-one 
• 80095-96-1 1-<3,4-Dihydro-3-(3-methoxyphenyl)-4-oxo-2-chinazolinylmethyl>-1H-1,2,3-triazol-4,5-dicarbonsaeuredimethylester 
• 81541-39-1 R,S-Essigsaeure(acetamido-<3,4-dihydro-3-<3-methoxyphenyl>-4-oxo-2-chinazolinyl>-methyl)ester 
• 81557-46-2 R,S-N-(<3,4-Dihydro-3-<3-methoxyphenyl>-4-oxo-2-chinazolinyl>-hydroxymethyl)acetamid 
• 345228-23-1 2-Aminomethyl-3,4-dihydro-3-(3-methoxyphenyl)-4-chinazolinon 
• 80096-29-3 2-Azidomethyl-3,4-dihydro-3-(3-methoxyphenyl)-4-chinazolinon 

Relevant articles and documents

Novel 2,4- thiazolidinediones: Synthesis, in?vitro cytotoxic activity, and mechanistic investigation

Two thiazolidinedione scaffolds different in the position of the thiazolidinedione ring in the molecule were tested for in?vitro cytotoxic activity in a panel of human cancer cell lines namely, prostate cancer cells PC-3, breast carcinoma cells MDA-MB-231

Synthesis of novel new 2-(2-(4-((3,4-dihydro-4-oxo-3-aryl quinazolin-2-yl)methyl)piperazin-1-yl)acetoyloxy)-2-phenyl acetic acid esters

Stereoselective diazotization of (S)-2-amino-2-phenyl acetic acid (L-phenyl glycine) (4) with NaNO2 in 6% H2SO4 in a mixture of acetone and water gave optically pure (S)-2-hydroxy-2-phenyl acetic acid (L-mandelic acid) (5). Esterification, gave (S)-2-hydroxy-2-phenyl acetic acid esters (6). The latter was treated with chloroacetyl chloride in the presence of triethylamine (TEA) in dichloromethane (DCM) to yield (S)-2-chloroacetyloxy phenyl acetic acid ester (2). In another sequence, the reaction of 2-(chloromethyl)-3-arylquinazolin- 4(3H)-one (9) treated with N-Boc piperazine, followed by deprotection of the Boc group, to obtain 3-aryl-2-((piperazin-1-yl)methyl) quinazolin-4(3H)-one (3). Reaction of 2 with 3 in the presence of K2CO3 and KI gave the title compound, 2-(2-(4-((3,4-dihydro-4-oxo-3-arylquinazolin-2-yl)methyl)piperazin-1-yl) acetoyloxy)-2-phenyl acetic acid esters (1). The structures of all the new compounds obtained in the present work are supported by spectral and analytical data. Copyright Taylor & Francis Group, LLC.

Quinazolinones, 2. Syntheses and Some Reactions of 2-Azido-methyl-3-aryl-4-quinazolinones

Starting with the chloromethyl compounds 7 the new 2-azidomethyl-3-aryl-4-quinazolinones 8a-h were prepared, some of which have been reduced so far to the corresponding amines 9a, b, e, g by H2S in good yield.As a first example for the capability of the a