76542-79-5Relevant academic research and scientific papers
N-Protected N-Carboxyanhydrides IX. Synthesis of N-Aralkyl α-Amino Acid N-Carboxyanhydrides by Carbonyl Insertion with Bis(N-Succinimidyl)Carbonate
Halstroem, John,Kovacs, Karoly
, p. 462 - 465 (2007/10/02)
Cyclization of N-aralkyl α-amino acids to N-carboxyanhydrides without using phosgene is reported.The weakly acidic reaction conditions allow a safe preparation od new acid-labile derivatives in peptide synthesis.
NEW N-AMINO ACID DERIVATIVES OF DAUNORUBICIN
Martelli, S.
, p. 881 - 891 (2007/10/02)
New N-amino acid derivatives of daunorubicin have been obtained by acylation of daunorubicin amino group with α, β and γ amino acids and their N,N-dibenzyl derivatives.The results of the antitumor activity determination have evidenced that the change of the amino function position in the daunorubicin derivatives, in relation to that of the parent antibiotic, causes the loss of activity.
