76562-58-8

Upstream product

• 76562-56-6 6-amino-1-(4-methoxyphenyl)-3-methyluracil 
• 21260-49-1 N-methyl-N'-(p-methoxyphenyl)urea 
• 76562-57-7 1-p-Methoxyphenyl-3-methyl-5-nitroso-6-aminouracil 

Downstream Products

• 176379-50-3 8-(3,5-di-tert-butyl-4-hydroxyphenyl)-3-(4-methoxyphenyl)-1-methylpurine-2,6-dione 
• 76562-53-3 [3-(4-Methoxy-phenyl)-1-methyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-yl]-carbamic acid ethyl ester 
• 76562-52-2 [3-(4-Methoxy-phenyl)-1-methyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-yl]-carbamic acid methyl ester 

Relevant academic research and scientific papers

1-arylpyrimidine derivatives and pharmaceutical use thereof

The present invention relates to 1-arylpyrimidine derivatives represented by general formula (I): STR1 wherein R1 is H, alkyl or aralkyl; Ar is 1-naphthyl, or a substituted or unsubstituted phenyl group; R4 is a substituted phenyl, a substituted styryl, 1-methylcyclohexyl, 4-methylcyclohexyl, 4-oxo-4H-pyran-2-yl or 2-oxo-2H-pyran-5-yl group; R5 and R6 are each independently H or alkyl; R3 is H, and R7 and R8 are combined together to be oxo, or else R3 and R7 are combined together to be another direct bond, and R5 and R8 are combined together to be a direct bond, or pharmaceutically acceptable salts thereof; and methods for treating allergic diseases with such compounds.

Synthesis & Anthelmintic Activity of Some New 1,3-Disubstituted 1,2,3,6-Tetrahydro-2,6-dioxo-8-purinyl Carbamates

A series of new 1,3-disubstituted 1,2,3,6-tetrahydro-2,6-dioxo-8-purinyl carbamates (VIIa-r) has been synthesized by the condensation of appropriate 5,6-diaminouracils (V) with 1,3-bis(alkoxycarbonyl-S-methyl)isothioureas (VI) and screened for their anthelmintic activity against Nematospiroides dubius, Hymenolepis nana and Ancylostoma ceylanicum.Selected compounds have also been tested for their anthelmintic activity against Nippostrongyles brasiliensis in rats.Three compounds VIIc, VIId and VIIe show moderate antihookworm activity against A. ceylanicum by clearing the worm load by 87, 67 and 58percent respectively at 2*250 mg/kg (p.o.) dose.None of the compounds is found active against N. dubius, H. nana and N. brasiliensis