76563-39-8

Upstream product

• 1926-80-3 methyl 6-aminocaproate hydrochloride 
• 605-65-2 5-(dimethylamino)naphth-1-ylsulfonyl chloride 
• 60-32-2 6-aminohexanoic acid 
• 351351-89-8 6-(5-dimethylamino-naphthalene-1-sulfonylamino)-hexanoic acid methyl ester 

Downstream Products

• 1161600-98-1 N-(benzyloxy)-6-(5-(dimethylamino)naphthalene-1-sulfonamido)hexanamide 

Relevant academic research and scientific papers

Protein assisted fluorescence enhancement of a dansyl containing fluorescent reagent: Detection of Hg+ ion in aqueous medium

Intramolecular charge transfer (ICT) based fluorescent reagents containing a dansyl fluorophore have been synthesized and characterized. The reagent 1 and its complex, 1+Hg2+ in sodium acetate buffer (pH 6.7) revealed considerable fluorescence

Covalent Protein Labeling by Enzymatic Phosphocholination

We present a new protein labeling method based on the covalent enzymatic phosphocholination of a specific octapeptide amino acid sequence in intact proteins. The bacterial enzyme AnkX from Legionella pneumophila has been established to transfer functional phosphocholine moieties from synthetically produced CDP-choline derivatives to N-termini, C-termini, and internal loop regions in proteins of interest. Furthermore, the covalent modification can be hydrolytically removed by the action of the Legionella enzyme Lem3. Only a short peptide sequence (eight amino acids) is required for efficient protein labeling and a small linker group (PEG-phosphocholine) is introduced to attach the conjugated cargo.

Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent

Here we report on a novel fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain with potential use as an imaging agent. Compound 2 incorporated a heptyl side chain and dansyl moiety onto the parent compound phenytoin and produced greater displacement of BTX from sodium channels and greater functional blockade with greatly reduced toxicity. Compound 2 reduced mechano-allodynia in a rat model of neuropathic pain and was visualized ex vivo in sensory neuron axons with two-photon microscopy. These results suggest a promising strategy for developing novel sodium channel inhibitors with imaging capabilities.

Fluorescent-tagged sp2-iminosugars with potent β-glucosidase inhibitory activity

New fluorescently-labelled sp2-iminosugars based on the 5N,6S-[N′-(4-aminobutyl)iminomethylidene]-6-thionojirimycin skeleton have been synthesized as photoprobes to monitor glycosidase binding. Dansyl, dapoxyl and coumarin fluorophores were app

HISTONE DEACETYLASE INHIBITORS

Novel histone deacetylase inhibitors, including novel fluorescent histone deacetylase inhibitors, are described. Methods for making and using the same, e.g., to treat cancer, are provided.

Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes

(Chemical Equation Presented) The design, synthesis, and biological evaluation of a series of (+)-discodermolide molecular probes possessing photoaffinity and fluorescent appendages has been achieved. Stereoselective olefin cross-metathesis comprised a ke

Powerful probes for glycosidases: Novel, fluorescently tagged glycosidase inhibitors

1-Amino-1,2,5-trideoxy-2,5-imino-D-mannitol was fluorescently tagged by reaction with dansyl chloride at N-1 or by attachment of a dansyl amide bearing spacer to this centre. Compounds obtained are highly potent inhibitors of β-glucosidase exhibiting Ki values in the single figure nanomolar range. The 1-N-dansyl substituted inhibitor was successfully exploited for binding studies with β-glucosidase from Agrobacterium sp. employing fluorescence spectrometric methods.