76571-64-7

Upstream product

• 82754-95-8 N-acetyl-L-alanylglycine ethyl ester 
• 952301-39-2 [2-¹³C]-2-azidoacetamide 
• 598-41-4 H-Gly-NH₂ 
• 2503-32-4 ethyl N-(benzyloxycarbonyl)-L-alanylglycinate 
• 1668-10-6 glycinamide hydrochloride 
• 82754-94-7 ((S)-2-Amino-propionylamino)-acetic acid ethyl ester; compound with toluene-4-sulfonic acid 

Relevant academic research and scientific papers

Water-soluble phosphinothiol reagents

Water soluble reagents and methods for the formation of an amide bond between a phosphinothioester and an azide in an aqueous medium. The phosphinothioester is generated using a water-soluble phosphinothiol reagent. This reaction allows formation of an amide bond between a wide variety of chemical species including amino acids, peptides or protein fragments in an aqueous solution. Of particular interest, this reaction allows for the formation of an amide bond in a physiological setting. In a specific embodiment, this invention provides reagents and methods for peptide ligation in an aqueous medium. The reaction eliminates the need for a cysteine residue and is traceless leaving no residual atoms in the ligated peptide product.

Water-soluble phosphinothiols for traceless Staudinger ligation and integration with expressed protein ligation

The traceless Staudinger ligation is an effective means to synthesize an amide bond between two groups of otherwise orthogonal reactivity: a phosphinothioester and an azide. An important application of the Staudinger ligation is in the ligation of peptide

Aqueous Solutions Containing Amino Acids and Peptides

The energetics of the interactions occuring between some N-acetyl amino acid amides and some N-acetyl peptide amides in aqueous solutions at 298.15 K have been investigated.Osmotic coefficients of solutions containing N-acetylglycinamide (G), N-acetyl-L-a