76574-92-0

Basic information

• Product Name: 6-(2,6-dichlorophenyl)-2,4-dimethylpyrido[2,3-d]-pyrimidin-7-amine
• Synonyms: 6-(2,6-dichlorophenyl)-2,4-dimethylpyrido[2,3-d]-pyrimidin-7-amine
• CAS NO: 76574-92-0
• Molecular Weight: 319.193
• Mol File: 76574-92-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-(2,6-dichlorophenyl)-2,4-dimethylpyrido[2,3-d]-pyrimidin-7-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2,6-dichlorophenyl)-2,4-dimethylpyrido[2,3-d]-pyrimidin-7-amine(76574-92-0)
• EPA Substance Registry System: 6-(2,6-dichlorophenyl)-2,4-dimethylpyrido[2,3-d]-pyrimidin-7-amine(76574-92-0)

Safety Data

• Hazardous Substances Data: 76574-92-0(Hazardous Substances Data)

Upstream product

• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 34684-87-2 4-amino-2,6-dimethylpyrimidine-5-carbonitrile 
• 3215-64-3 2,6-dichlorophenylacetonitrile 
• 76574-47-5 2,6-dimethyl-4-amino-5-pyrimidinecarbaldehyde 

Downstream Products

• 84279-26-5 N-[6-(2,6-Dichloro-phenyl)-2,4-dimethyl-pyrido[2,3-d]pyrimidin-7-yl]-acetamide 

Relevant articles and documents

Antihypertensive Activity of 6-Arylpyridopyrimidin-7-amine Derivatives

A series of 51 6-arylpyridopyrimidin-7-amine derivatives was prepared and evaluated for antihypertensive activity in the conscious spontaneously hypertensive rat.A number of these compounds, notably 6-(2,6-dichlorophenyl)-2-methylpyridopyrimidin-7-amine (36), lowered blood pressure in these rats in a gradual and sustained manner to normotensive levels at oral doses of 10-50 mg/kg.Normalized blood pressure levels could then be maintained by single daily oral doses.The effect of structural variation in the 6-aryl group and in the 2 and 4 positions of the pyridopyrimidine ring on activity is reported and discussed.