76580-08-0Relevant academic research and scientific papers
Catalytic α-Arylation of Ketones with Heteroaromatic Esters
Isshiki, Ryota,Takise, Ryosuke,Itami, Kenichiro,Muto, Kei,Yamaguchi, Junichiro
supporting information, p. 2599 - 2603 (2017/10/31)
Heteroaromatic esters were found to be applicable as an arylating agent for the Pd-catalyzed α-arylation of ketones in a decarbonylative fashion. The use of our in-house ligand, dcypt, enabled this unique bond formation. Considering the ubiquity and low cost of aromatic esters, the present work will allow for rapid access to valuable α-aryl carbonyl compounds.
Selective Metal-Free Deoxygenation of Unsymmetrical 1,2-Dicarbonyl Compounds by Chlorotrimethylsilane and Sodium Iodide
Yuan, Ling-Zhi,Renko, Dolor,Khelifi, Ilhem,Provot, Olivier,Brion, Jean-Daniel,Hamze, Abdallah,Alami, Mouad
supporting information, p. 3238 - 3241 (2016/07/14)
For the first time, the combination of chlorotrimethylsilane with NaI is used as a selective reducting system toward 1,2-diketones. This combination is successfully evaluated with several unsymmetrically benzil derivatives, which are reduced in good yield
LIGAND, NICKEL COMPLEX COMPRISING LIGAND, AND REACTION USING NICKEL COMPLEX
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Paragraph 0282; 0284; 0285, (2016/10/07)
PROBLEM TO BE SOLVED: To provide a method for directly carrying out arylation, especially α-arylation, of a carbonyl compound or a thiocarbonyl compound by using a more inexpensive phenol derivative and a nickel catalyst, and to provide a novel nickel cat
Nickel-catalyzed α-arylation of ketones with phenol derivatives
Takise, Ryosuke,Muto, Kei,Yamaguchi, Junichiro,Itami, Kenichiro
supporting information, p. 6791 - 6794 (2014/07/08)
The nickel-catalyzed α-arylation of ketones with readily available phenol derivatives (esters and carbamates) provides access to useful α-arylketones. For this transformation, 3,4-bis(dicyclohexylphosphino) thiophene (dcypt) was identified as a new, enabling, air-stable ligand for this transformation. The intermediate of an assumed C-O oxidative addition was isolated and characterized by X-ray crystal-structure analysis. The nickel-catalyzed α-arylation of ketones with readily available phenol derivatives (esters and carbamates) provides access to useful α-arylketones. The use of 3,4-bis(dicyclohexylphosphino)thiophene (dcypt) as an air-stable ligand enables this transformation. The intermediate of an assumed C-O oxidative addition was isolated and characterized by X-ray crystal-structure analysis.
