76581-81-2Relevant articles and documents
From penicillin to penem and carbapenem. VII. Synthesis and antibacterial activity of penem derivatives
Fujimoto,Iwano,Hirai,Sugawara
, p. 999 - 1014 (2007/10/02)
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FROM PENICILLIN TO PENEM AND CARBAPENEM. II. SYNTHESIS OF 3,4-DISUBSTITUTED AZETIDINONE DERIVATIVES FROM 6,6-BIS(PHENYLSELENYL)PENICILLANATE
Hirai, Koichi,Iwano, Yuji,Fujimoto, Katsumi
, p. 4021 - 4024 (2007/10/02)
6,6-Bis(phenylselenyl)penicillanate 2a was converted into 6-1'-(R)-hydroxyethyl substituted penicillanate 5 in high yield.Compound 5 was deselenylated to 10.Oxidation, and then the basic epimerization of cis sulfone 11 gave trans sulfone derivative 12.The trans sulfone 12 was degraded to the monocyclic β-lactams 14, 15 which are important precursors for the carbapenem synthesis.