76591-81-6

Upstream product

• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 1228801-85-1 1,2-bis(ethoxycarbonyl)-3-methyl-5-(4-nitrophenyl)-2,3-dihydro-1H-1,2,4-triazole-3-carboxylic acid 
• 62-55-5 thioacetamide 
• 99-77-4 ethyl 4-nitrobenzoate 
• 76226-64-7 4-(p-nitro-α-methylthiobenzylidene)morpholinium iodide 
• 60576-61-6 acetamidrazone 

Downstream Products

• 518065-43-5 4-(5-methyl-4H-1,2,4-triazol-3-yl)aniline 

Relevant academic research and scientific papers

Synthesis and study of novel 1,2,4-triazolylacetic acid derivatives

[Figure not available: see fulltext.] A range of 1,2,4-triazolylacetic acids and their derivatives with various substituents at the triazole ring position 3 have been synthesized. The properties of the obtained compounds were studied, showing that: 1) triazolylacetic esters are strong acylating agents; 2) all the obtained triazolylacetic acids underwent decarboxylation when heated to the melting point; 3) the CH2 group in the acetyl moiety can react as methylene component in condensation reactions.

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

Synthesis of 1,2,4-Triazolines and triazoles utilizing oxazolones

We describe herein a convenient method for the synthesis of 1,2,4-triazolines using oxazolones and azodicarboxylates. Subsequent treatment of these 1,2,4-triazolines with NaOH provides efficient access to the corresponding triazoles.