765923-81-7Relevant academic research and scientific papers
A pyrrolysine analogue for protein click chemistry
Fekner, Tomasz,Li, Xin,Lee, Marianne M.,Chan, Michael K.
supporting information; experimental part, p. 1633 - 1635 (2009/06/30)
(Chemical Equation Presented) Ignoring the STOP sign: A pyrrolysine analogue bearing a terminal alkyne was site-specifically incorporated into recombinant calmodulin (CaM) through a UAG codon. The resulting protein was labeled with an azide-containing dye using a copper(I)-catalyzed click reaction. Subsequent application of an orthogonal cysteine tagging method yielded a CaM labeled with two distinct fluorophores that enabled its study by FRET spectroscopy.
Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartyl protease inhibitors. Nitroaldol methodology toward 2,3-substituted tetrahydrofurans
Hanessian, Stephen,Brassard, Martin
, p. 7621 - 7628 (2007/10/03)
The Shibasaki heterobimetallic Binol lanthanide, and Trost dinuclear zinc catalysts were studied in a nitroaldol reaction of 3-methyl-1-nitrobutane with a chiral non-racemic tetrahydrofuran aldehyde. Other methods utilized KF, Amberlyst A-21, and t-BuOK a
