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1H-Isoindol-1-one, 4-(4-aminophenyl)-2,3-dihydrois a chemical compound with the molecular formula C16H16N2O. It is a dihydroisoindolone derivative with potential anti-cancer activity. 1H-Isoindol-1-one, 4-(4-aminophenyl)-2,3-dihydrohas been studied for its potential use in cancer treatment due to its ability to inhibit the growth of cancer cells. It is also known to exhibit anti-inflammatory and anti-angiogenic properties, making it a potential candidate for the development of new drugs for cancer therapy. Additionally, research has shown that 1H-Isoindol-1-one, 4-(4-aminophenyl)-2,3-dihydro- may have neuroprotective effects, and it has been the subject of studies for its potential use in the treatment of neurodegenerative diseases.

765948-62-7

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765948-62-7 Usage

Uses

Used in Pharmaceutical Industry:
1H-Isoindol-1-one, 4-(4-aminophenyl)-2,3-dihydrois used as a potential anti-cancer agent for its ability to inhibit the growth of cancer cells. Its anti-inflammatory and anti-angiogenic properties also make it a promising candidate for the development of new drugs for cancer therapy.
Used in Neurodegenerative Disease Treatment:
1H-Isoindol-1-one, 4-(4-aminophenyl)-2,3-dihydrois used as a potential neuroprotective agent due to its neuroprotective effects, making it a candidate for the treatment of neurodegenerative diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 765948-62-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,5,9,4 and 8 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 765948-62:
(8*7)+(7*6)+(6*5)+(5*9)+(4*4)+(3*8)+(2*6)+(1*2)=227
227 % 10 = 7
So 765948-62-7 is a valid CAS Registry Number.

765948-62-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-aminophenyl)-2,3-dihydroisoindol-1-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:765948-62-7 SDS

765948-62-7Relevant academic research and scientific papers

Isoindolinone kinase inhibitors

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Page/Page column 11, (2010/02/10)

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Isoindolinone ureas: A novel class of KDR kinase inhibitors

Curtin, Michael L.,Frey, Robin R.,Heyman, H. Robin,Sarris, Kathy A.,Steinman, Douglas H.,Holmes, James H.,Bousquet, Peter F.,Cunha, George A.,Moskey, Maria D.,Ahmed, Asma A.,Pease, Lori J.,Glaser, Keith B.,Stewart, Kent D.,Davidsen, Steven K.,Michaelides, Michael R.

, p. 4505 - 4509 (2007/10/03)

A series of substituted isoindolinone ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 14c, are potent inhibitors of KDR both enzymatically (50nM) and cellularly (≤100nM). A 3D KDR/CDK2/MAP kinase overlay model with several structurally related tyrosine kinase inhibitors was used to predict the binding interactions of the isoindolinone ureas with the KDR active site.

ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS

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, (2010/02/09)

Compounds having the formula, (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds and compositions containing the compounds.

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