765962-55-8

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 16290-26-9 3,4-dihydroxybenzylamine hydrobromide 
• 17345-61-8 3,4-dihydroxybenzonitrile 
• 1259425-46-1 C₁₉H₃₃NO₂Si₂ 

Downstream Products

• 1407767-72-9 N-(3,4-dihydroxybenzyl)-4-methyl-N-(3,4,5-trimethoxybenzyl)benzenesulfonamide 
• 1407768-64-2 2-fluoro-9,10,11-trimethoxy-6-toluenesulfonyl-6,7-dihydro-5H-dibenzo[c,e]azepin-3-ol 
• 1407768-62-0 3-fluoro-9,10,11-trimethoxy-6-toluenesulfonyl-6,7-dihydro-5H-dibenzo[c,e]azepin-2-ol 
• 1407768-11-9 9,10,11-trimethoxy-6-toluenesulfonyl-6,7-dihydro-5H-dibenzo[c,e]azepine-2,3-diol 

Relevant academic research and scientific papers

Bioinspired Design Provides High-Strength Benzoxazine Structural Adhesives

A synthetic strategy to incorporate catechol functional groups into benzoxazine thermoset monomers was developed, leading to a family of bioinspired small-molecule resins and main-chain polybenzoxazines derived from biologically available phenols. Lap-she

TRPV1 MODULATOR COMPOUNDS

The present invention relates to TRPV1 modulator compounds of formula (I) or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein m is an integer selected from 1 to 3; R1, R2, R6 and R6', are independently selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, and (C3-C6)cycloalkyl, being these groups optionally substituted; R3 is hydrogen or halogen; R4 is selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, (C3-C6)cycloalkyl, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted; and R5 is selected from (C3-C28)alkyl, unsaturated (C3-C28)hydrocarbon, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted. It also relates to a process for their preparation, to pharmaceutical, veterinary or cosmetic compositions containing them, and to their pharmaceutical, veterinary and cosmetic applications.

Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders

Despite being an old molecule, capsaicin is still a hot topic in the scientific community, and the development of new capsaicinoids is a promising pharmacological approach in the management of skin disorders related to inflammation and pruritus. Here we report the synthesis and the evaluation of capsaicin soft drugs that undergo deactivation by the hydrolyzing activity of skin esterases. The implanting of an ester group in the lipophilic moiety of capsaicinoids by the Passerini multicomponent reaction affords both agonists and antagonists that retain transient receptor potential vanilloid 1 channel (TRPV1) modulating activity and, at the same time, are susceptible to hydrolysis. The most promising antagonist identified shows in vivo anti-nociceptive activity on pruritus and hyperalgesia without producing hyperthermia, thus validating it as novel treatment for dermatological conditions that implicate TRPV1 channel dysfunction.

Regiocomplementary synthesis of fluorinated bridged biphenyls

Complementary synthesis of two kinds of fluorinated bridged biphenyls has been developed by the combination of oxidative carbon-carbon bond formation and deoxyfluorination. Georg Thieme Verlag Stuttgart · New York.