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Upstream product

• 2367-82-0 1,2,3,5-tetrafluorobenzene 
• 314-41-0 1,2,3,5-tetrafluoro-4-nitrobenzene 
• 29632-74-4 2-fluro-4-iodoaniline 

Downstream Products

• 923032-72-8 (2,3-difluoro-5-methoxy-6-nitro-phenyl)-(2-fluoro-4-iodo-phenyl)-amine 
• 1415582-04-5 (R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide 
• 1311400-85-7 cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzooxazol-7-yl]amide 
• 1311401-82-7 2-(benzyloxymethyl)-N-(4,5-difluoro-6-(2-fluoro-4-iodophenylamino)benzofuran-7-yl)cyclopropane-1-sulfonamide 
• 1311401-81-6 1-(2-(benzyloxymethyl)cyclopropylsulfonyl)-4,5-difluoro-3-(2-fluoro-4-iodophenyl)-1H-benzofuro[6,7-d]imidazol-2(3H)-one 
• 1311401-80-5 N-(4,5-difluoro-6-(2-fluoro-4-iodophenylamino)benzofuran-7-yl)-1-(2-oxoethyl)cyclopropane-1-sulfonamide 
• 1311401-79-2 1-allyl-N-(4,5-difluoro-6-(2-fluoro-4-iodophenylamino)benzofuran-7-yl)cyclopropane-1-sulfonamide 
• 1311401-78-1 1-(1-allylcyclopropylsulfonyl)-4,5-difluoro-3-(2-fluoro-4-iodophenyl)-1H-benzofuro[6,7-d]imidazol-2(3H)-one 
• 1311401-77-0 1-(cyclopropylsulfonyl)-4,5-difluoro-3-(2-fluoro-4-iodophenyl)-1H-benzofuro-[6,7-d]imidazol-2(3H)-one 
• 1311401-76-9 4,5-difluoro-3-(2-fluoro-4-iodophenyl)-1H-benzofuro[6,7-d]imidazol-2(3H)-one 
• 1311401-75-8 4,5-difluoro-N₆-(2-fluoro-4-iodo-phenyl)-benzofuran-6,7-diamine 
• 1311401-74-7 (4,5-difluoro-7-nitro-benzofuran-6-yl)-(2-fluoro-4-iodo-phenyl)-amine 
• 1311401-48-5 8-cyclopropanesulfonyl-4,5-difluoro-6-(2-fluoro-4-iodophenyl)-6,8-dihydroimidazo[4',5':3,4]benzo[1,2-d]oxazol-7-one 
• 1311401-28-1 4,5-difluoro-6-(2-fIuoro-4-iodophenyl)-6,8-dihydroimidazo[4',5':3,4]benzo[1,2-d]oxazol-7-one 

Relevant academic research and scientific papers

HETEROCYCLIC SULFONAMIDE DERIVATIVES

The present invention relates to compounds: and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases like cancer and inflammation.

HETEROCYCLIC SULFONAMIDE DERIVATIVES

The present invention relates to compounds (I) and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases like cancer and inflammation.

HETEROCYCLIC SULFONAMIDE DERIVATIVES

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases (e.g., cancer and inflammation).

NOVEL MEK INHIBITORS, USEFUL IN THE TREATMENT OF DISEASES

The invention pertains to compound of Formula (I) wherein X, Y, Z, R1, R2, R3, R4, A and A' are as described hereinabove. Formula (I) and (II) compounds can be used in pharmaceutical compositions, useful for the treatment of diseases

N-(ARYLAMINO)-SULFONAMIDE INHIBITORS OF MEK

This invention concerns N-(2-arylamino) aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.

N-ARYL-N'ALKYL SULFAMIDES AS MEK INHIBITORS

This invention concerns N-(ortho phenylaminoaryl), N′-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases.