7661-28-1

Upstream product

• 7661-13-4 3-bromo-N-(4-iodophenyl)propanamide 
• 21261-74-5 3-chloro-N-(4-iodophenyl)propionamide 
• 540-37-4 p-aminoiodobenzene 
• 930-21-2 2-azetidinone 
• 589-87-7 1,4-bromoiodobenzene 

Downstream Products

• 38470-27-8 6-Iod-2,3-dihydrochinolin-4(1H)-on 

Relevant academic research and scientific papers

Method of fluorination using iodonium ylides

A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.

Synthesis of 2,3-dihydro-4(1H)-quinolones and the corresponding 4(1H)-quinolones via low-temperature fries rearrangement of N-arylazetidin-2- ones

N-Arylazetidin-2-ones of the general form 1, which are readily prepared by GoldbergBuchwald-type copper-catalyzed coupling of N-unsubstituted azetidin-2-ones with the relevant aryl halide or using Mitsunobu cyclization processes, undergo smooth Fries-rearrangement in triflic acid at 018°C to give the isomeric 2,3-dihydro-4(1H)-quinolones (2). Dehydrogenation of the latter compounds using 10% Pd on C in 1.0M aqueous sodium hydroxide/propan-2-ol mixtures at ca. 82°C provides the corresponding 4(1H)-quinolones (3).