7661-30-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-bromophenyl)pyrrolidin-2-one serves as a key intermediate in the synthesis of a variety of drugs and compounds, contributing to the development of new medications and therapeutic agents.
Used in Organic Chemical Reactions:
As a building block, 1-(2-bromophenyl)pyrrolidin-2-one is employed in organic chemical reactions to construct more complex molecules, facilitating the creation of novel chemical entities with potential applications in various industries.
Used in Laboratory Settings:
1-(2-bromophenyl)pyrrolidin-2-one functions as a reagent in laboratory research, aiding scientists in conducting experiments and advancing the understanding of chemical reactions and processes.

InChI:InChI=1/C10H10BrNO/c11-8-4-1-2-5-9(8)12-7-3-6-10(12)13/h1-2,4-5H,3,6-7H2

Upstream product

• 615-36-1 2-bromoaniline 
• 616-45-5 2-pyrrolidinon 
• 583-55-1 1-Bromo-2-iodobenzene 
• 4641-57-0 1-phenylpyrrolidin-2-one 
• 27131-40-4 N-(2-Bromo-phenyl)-4-chloro-butyramide 

Downstream Products

• 155186-37-1 N-(2-bromophenyl)pyrrolidine-2-thione 
• 186667-97-0 diethyl [1-(2-bromophenyl)pyrrolidin-2-ylidene]malonate 

Relevant academic research and scientific papers

Heterogeneous CuII-catalysed solvent-controlled selective N-arylation of cyclic amides and amines with bromo-iodoarenes

A selective N-arylation of cyclic amides and amines in DMF and water, respectively, catalysed by CuII/Al2O3 has been achieved. This protocol has been employed for the synthesis of a library of arenes bearing a cyclic amide and an amine moiety at two ends, including a few scaffolds of therapeutic importance. The mechanism has been established based on detailed electron paramagnetic resonance (EPR) spectroscopy, X-ray photoelectron spectroscopy (XPS), UV diffuse reflectance spectroscopy (DRS) and inductively coupled plasma-mass spectrometry (ICP-MS) studies of the catalyst at different stages of the reaction. The CuII/Al2O 3 catalyst was recovered and recycled for subsequent reactions. One over the other: A selective N-arylation of cyclic amides and amines in DMF and water, respectively, catalyzed by CuII/Al2O3 has been achieved (see scheme). This protocol has been employed for the synthesis of a library of arenes bearing cyclic amide and amine moieties at two ends including a few scaffolds of therapeutic importance. The mechanism has been established based on detailed spectroscopic studies (FG=functional group). Copyright

Scope and selectivity in palladium-catalyzed directed C-H bond halogenation reactions

Palladium-catalyzed ligand directed C-H activation/halogenation reactions have been extensively explored. Both the nature of the?directing group and the substitution pattern on the arene ring of the substrate lead to different reactivity profiles, and often different and complementary products, in the presence and absence of the catalyst.

Reformatsky reactions with N-arylpyrrolidine-2-thiones: Synthesis of tricyclic analogues of quinolone antibacterial agents

A convenient synthesis of 5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-α]quinoline-4-carboxylic acids, tricylic analogues of the quinolone antibiotics, is described. Key steps in the route are a novel zinc-mediated Reformatsky reaction between diethyl bromomalonate and N-arylpyrrolidine-2-thione 18, and cyclisation of the resulting diethyl pyrrolidinylidenemalonate intermediates 19 in polyphosphoric acid. The products proved to be devoid of biological activity.

A versatile synthesis of tricyclic analogues of quinolone antibacterial agents: Use of a novel Reformatsky reaction

A simple synthesis of tricyclic analogues of the quinolone antibiotics bearing a diverse range of substituents on the aromatic ring is described. The key steps involve unprecedented Reformatsky reaction between diethyl bromomalonate and N-arylpyrrolidine-2-thiones 8, followed by cyclisation of the resulting enaminone intermediates 9 in polyphosphoric acid.