7661-30-5

Basic information

• Product Name: 1-(2-bromophenyl)pyrrolidin-2-one
• Synonyms: 1-(2-bromophenyl)pyrrolidin-2-one
• CAS NO: 7661-30-5
• Molecular Formula: C₁₀H₁₀BrNO
• Molecular Weight: 240.0965
• Mol File: 7661-30-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 403.4°C at 760 mmHg
• Flash Point: 197.8°C
• Appearance: /
• Density: 1.532g/cm³
• Vapor Pressure: 1.02E-06mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1-(2-bromophenyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromophenyl)pyrrolidin-2-one(7661-30-5)
• EPA Substance Registry System: 1-(2-bromophenyl)pyrrolidin-2-one(7661-30-5)

Safety Data

• Hazardous Substances Data: 7661-30-5(Hazardous Substances Data)

Usage

Description

1-(2-bromophenyl)pyrrolidin-2-one, also known as 2-Bromophenyl-2-pyrrolidinone, is an organic compound characterized by its molecular formula C11H10BrNO. It presents as a white to off-white crystalline powder, primarily utilized in research and chemical synthesis. As a derivative of pyrrolidin-2-one, this compound features a bromine atom attached to a phenyl group, which endows it with unique chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
1-(2-bromophenyl)pyrrolidin-2-one serves as a key intermediate in the synthesis of a variety of drugs and compounds, contributing to the development of new medications and therapeutic agents.
Used in Organic Chemical Reactions:
As a building block, 1-(2-bromophenyl)pyrrolidin-2-one is employed in organic chemical reactions to construct more complex molecules, facilitating the creation of novel chemical entities with potential applications in various industries.
Used in Laboratory Settings:
1-(2-bromophenyl)pyrrolidin-2-one functions as a reagent in laboratory research, aiding scientists in conducting experiments and advancing the understanding of chemical reactions and processes.

InChI:InChI=1/C10H10BrNO/c11-8-4-1-2-5-9(8)12-7-3-6-10(12)13/h1-2,4-5H,3,6-7H2

Upstream product

• 616-45-5 2-pyrrolidinon 
• 583-55-1 1-Bromo-2-iodobenzene 
• 615-36-1 2-bromoaniline 
• 4641-57-0 1-phenylpyrrolidin-2-one 
• 27131-40-4 N-(2-Bromo-phenyl)-4-chloro-butyramide 

Downstream Products

• 186667-97-0 diethyl [1-(2-bromophenyl)pyrrolidin-2-ylidene]malonate 
• 155186-37-1 N-(2-bromophenyl)pyrrolidine-2-thione 

Relevant articles and documents

Heterogeneous CuII-catalysed solvent-controlled selective N-arylation of cyclic amides and amines with bromo-iodoarenes

A selective N-arylation of cyclic amides and amines in DMF and water, respectively, catalysed by CuII/Al2O3 has been achieved. This protocol has been employed for the synthesis of a library of arenes bearing a cyclic amide and an amine moiety at two ends, including a few scaffolds of therapeutic importance. The mechanism has been established based on detailed electron paramagnetic resonance (EPR) spectroscopy, X-ray photoelectron spectroscopy (XPS), UV diffuse reflectance spectroscopy (DRS) and inductively coupled plasma-mass spectrometry (ICP-MS) studies of the catalyst at different stages of the reaction. The CuII/Al2O 3 catalyst was recovered and recycled for subsequent reactions. One over the other: A selective N-arylation of cyclic amides and amines in DMF and water, respectively, catalyzed by CuII/Al2O3 has been achieved (see scheme). This protocol has been employed for the synthesis of a library of arenes bearing cyclic amide and amine moieties at two ends including a few scaffolds of therapeutic importance. The mechanism has been established based on detailed spectroscopic studies (FG=functional group). Copyright

Reformatsky reactions with N-arylpyrrolidine-2-thiones: Synthesis of tricyclic analogues of quinolone antibacterial agents

A convenient synthesis of 5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-α]quinoline-4-carboxylic acids, tricylic analogues of the quinolone antibiotics, is described. Key steps in the route are a novel zinc-mediated Reformatsky reaction between diethyl bromomalonate and N-arylpyrrolidine-2-thione 18, and cyclisation of the resulting diethyl pyrrolidinylidenemalonate intermediates 19 in polyphosphoric acid. The products proved to be devoid of biological activity.