76629-17-9 Usage
Uses
Used in Pharmaceutical Industry:
ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE is used as a synthetic reagent for the preparation of antitrypanosomal and penicillin derivatives. Its application in this industry is due to its ability to facilitate the synthesis of these important drug classes, which are essential for treating various diseases and infections.
Used in Antitrypanosomal Applications:
ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE is used as a key intermediate in the synthesis of antitrypanosomal drugs, which are crucial for treating trypanosomiasis, a disease caused by the parasitic protozoa of the genus Trypanosoma. ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE's role in this application is to aid in the development of effective treatments against this parasitic infection.
Used in Penicillin Derivatives Applications:
ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE is used as a reagent in the production of penicillin derivatives, which are a class of antibiotics derived from the original penicillin molecule. ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE's application in this area is to enable the creation of new penicillin-based drugs with improved properties, such as enhanced efficacy, broader spectrum of activity, or reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 76629-17-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,6,2 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 76629-17:
(7*7)+(6*6)+(5*6)+(4*2)+(3*9)+(2*1)+(1*7)=159
159 % 10 = 9
So 76629-17-9 is a valid CAS Registry Number.
76629-17-9Relevant academic research and scientific papers
Synthesis and antitrypanosomal evaluation of some thiazole-containing amino acids and peptides
Van Bogaert,Haemers,Bollaert,Van Meirvenne,Brun,Smith,Fairlamb
, p. 387 - 397 (2007/10/02)
Several amino acids and peptides containing thiazole and thiazolidine residues were prepared. They were tested in vivo and in vitro as possible antitrypanosomal compounds. Some derivatives showed a slight activity. As they are structurally related to glut
The Chemistry of Some 2-Aminothiazol-4-ylacetic Acid Derivatives and the Synthesis of Derived Penicillins
Hardy, Kenneth D.,Harrington, Frank P.,Stachulski, Andrew V.
, p. 1227 - 1236 (2007/10/02)
The N-protected 2-aminothiazol-4-ylacetic acid derivatives (6), (11), (14), (16), (18), (26), (27), (30), (33), and (34) have been prepared.They are readily available by reaction of the corresponding 2-aminoethyl esters such as (1) with the appropriate acylating agents, generally giving a bis-carbamate of type (5), followed by saponification.The process is general for α-methylene, α-oximino, and α-aminosubstituents in the side-chain affording in the last case a route to differentially protected α-amino-α-(2-aminothiazol-4-yl)acetic acids such as (30).The optimum conditions for the acylations are described; the course of the saponification of the bis-carbamate esters is discussed and physical evidence for the structures of the derivatives is presented.The use of the protected acids (11) and (34) in the synthesis of the piperacillin analogue (38) is described.
