76629-36-2

Usage

Chemical structure

Consists of a substituted aniline group attached to a 1,2,4-oxadiazole ring.

Category

Categorized as an oxadiazole derivative.

Potential uses

Has potential uses in the fields of pharmaceuticals, agrochemicals, and materials science.

Unique properties

Has a unique chemical structure and properties, which may contribute to its potential applications.

Intermediate in synthesis

May have applications as an intermediate in the synthesis of various organic compounds.

Biological activities

Has potential biological activities that make it valuable in drug development.

Reactivity and functional groups

Its reactivity and functional groups make it versatile for use in organic synthesis and materials research.

Safety

Should be handled and used with care, following proper safety protocols and guidelines.

InChI:InChI=1/C9H9N3O/c1-6-11-9(13-12-6)7-4-2-3-5-8(7)10/h2-5H,10H2,1H3

Upstream product

• 118-48-9 isatoic anhydride 
• 118493-85-9 N-hydroxyacetamidine 
• 118493-85-9 acetamide oxime 
• 134-20-3 2-carbomethoxyaniline 
• 76629-46-4 3-methyl-5-(o-nitrophenyl)-1,2,4-oxadiazole 

Relevant academic research and scientific papers

Synthesis of benzoxazines, quinazolines and 4H-benzo[e][1,3]thiazine by ANRORC rearrangements of 1,2,4-oxadiazoles

1,2,4-Oxadiazoles undergo ANRORC (addition of nucleophile, ring-opening and ring-closure) rearrangements upon reaction with excess of n-butyllithium to give benzoxazines, benzothiazines, and quinazolines in good yields under mild conditions. Georg Thieme Verlag Stuttgart · New York.

Imidazoline derivatives as alpha-1A adrenoceptor ligands

Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.

2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.

A series of 2'-heteroaryl and 2'-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human alpha1A, alpha1B, and alpha1D receptor subtypes. Potent and selective alpha1A agonists have been identified in these series.

Derivatives of Phenylurea as Antagonists of Mice, Rat, Guinea Pig, and Rabbit 5-HT3 Receptors

1,2,4-Oxadiazolyl- and O-alkyloximinomethyl-substituted phenylureas equipotently bind to 5-HT3 receptors from different species in vitro in contrast to the normal 10-100 fold lower affinity for guinea pig ileal receptors. Compared to the in vitro receptor

Selective Reduction of Nitro-Heterocycles with Sodium Sulfide in Aqueous p-Dioxane

Nitro-heterocycles, particularly those containing halogen, were selectively reduced with sodium sulfide in aqueous p-dioxane to give the corresponding amino-heterocycles in 70-89percent yields.