76640-35-2

Upstream product

• 701-99-5 Phenoxyacetyl chloride 
• 76640-33-0 {[1-Benzo[1,3]dioxol-5-yl-meth-(Z)-ylidene]-amino}-acetic acid ethyl ester 
• 76640-34-1 ((2S,3R)-2-Benzo[1,3]dioxol-5-yl-4-oxo-3-phenoxy-azetidin-1-yl)-acetic acid ethyl ester 
• 76640-33-0 {[1-Benzo[1,3]dioxol-5-yl-meth-(Z)-ylidene]-amino}-acetic acid ethyl ester 
• 120-57-0 piperonal 
• 76640-34-1 (2-Benzo[1,3]dioxol-5-yl-4-oxo-3-phenoxy-azetidin-1-yl)-acetic acid ethyl ester 

Downstream Products

• 82934-73-4 1-(2-Benzo[1,3]dioxol-5-yl-4-oxo-3-phenoxy-azetidin-1-yl)-7,8-dimethoxy-9b-methylsulfanyl-1,4,5,9b-tetrahydro-azeto[2,1-a]isoquinolin-2-one 
• 82934-72-3 1-(2-Benzo[1,3]dioxol-5-yl-4-oxo-3-phenoxy-azetidin-1-yl)-9b-(4-methoxy-phenyl)-1,4,5,9b-tetrahydro-azeto[2,1-a]isoquinolin-2-one 
• 82952-62-3 2-(2-Benzo[1,3]dioxol-5-yl-4-oxo-3-phenoxy-azetidin-1-yl)-2a-phenyl-2,2a,9,10-tetrahydro-10a-aza-cyclobuta[a]phenanthren-1-one 
• 82934-74-5 7--2'',3''-dimethoxybenzooctem 
• 86977-93-7 (1S,9bR)-1-((2S,3R)-2-Benzo[1,3]dioxol-5-yl-4-oxo-3-phenoxy-azetidin-1-yl)-9b-methylsulfanyl-1,4,5,9b-tetrahydro-azeto[2,1-a]isoquinolin-2-one 
• 76640-36-3 1-p-Anisyl-3-azetidino>-4-(3,4-methylenedioxyphenyl)azetidin-2-one 
• 86977-95-9 (1S,9bR)-1-((2R,3S)-2-Benzo[1,3]dioxol-5-yl-4-oxo-3-phenoxy-azetidin-1-yl)-1,4,5,9b-tetrahydro-azeto[2,1-a]isoquinolin-2-one 

Relevant academic research and scientific papers

Studies on β-Lactams: Synthesis of Some Steroid-type Di-β-lactams

Schiff bases (1) on reaction with phenoxyacetyl chloride yield the β-lactam esters (2) which on further hydrolysis under mild basic conditions afford α-(2-oxo-1-azetidino)acetic acids (3).Reaction of the imines (4) with 3 using POCl3 and triethylamine fur

Conversion of some monocyclic β-lactams into novel di-β-lactams

Monocyclic β-lactams (V & XI) carrying a carboxy function have been used to annelate the Schiff bases (II & X) using POCl3 in the presence of triethylamine to obtain the di-β-lactams (VI & XII). Alternately, (VI) could also be prepared by annelation of the Schiff base (IX) derived from the α-amino-β-lactam (VIII), with phenoxyacetyl chloride.