76640-41-0

Upstream product

• 701-99-5 Phenoxyacetyl chloride 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 70216-04-5 {[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-amino}-acetic acid ethyl ester 
• 82934-66-5 [2-(3,4-Dimethoxy-phenyl)-4-oxo-3-phenoxy-azetidin-1-yl]-acetic acid ethyl ester 

Downstream Products

• 82934-69-8 1-[2-(3,4-Dimethoxy-phenyl)-4-oxo-3-phenoxy-azetidin-1-yl]-9b-p-tolyl-1,4,5,9b-tetrahydro-azeto[2,1-a]isoquinolin-2-one 
• 82934-70-1 1-[2-(3,4-Dimethoxy-phenyl)-4-oxo-3-phenoxy-azetidin-1-yl]-9b-(4-methoxy-phenyl)-1,4,5,9b-tetrahydro-azeto[2,1-a]isoquinolin-2-one 
• 82934-77-8 2-[2-(3,4-Dimethoxy-phenyl)-4-oxo-3-phenoxy-azetidin-1-yl]-2a-phenyl-2,2a,9,10-tetrahydro-10a-aza-cyclobuta[a]phenanthren-1-one 
• 76640-40-9 (3'S,4'R)-4'-Benzo[1,3]dioxol-5-yl-4-(3,4-dimethoxy-phenyl)-3-phenoxy-1'-p-tolyl-[1,3']biazetidinyl-2,2'-dione 
• 86977-92-6 7-azetidino>-6-methylthiobenzooctem 
• 76640-40-9 1-p-Tolyl-3-azetidino>-4-(3,4-methylenedioxyphenyl)azetidin-2-one 
• 87702-93-0 (3S,4R,3''S,4''R)-4',4''-Bis-benzo[1,3]dioxol-5-yl-4-(3,4-dimethoxy-phenyl)-1''-(4-methoxy-phenyl)-3-phenoxy-[1,3';1',3'']terazetidine-2,2',2''-trione 
• 86977-94-8 7-azetidino>-benzooctem 

Relevant academic research and scientific papers

Stereoselective solid-phase synthesis of 3,4-substituted azetidinones as key intermediates for mono- and multicyclic β-lactam antibiotics and enzyme inhibitors

The polymer-supported Staudinger reaction proceeded smoothly under mild conditions to give the corresponding β-lactams in good to high overall yields with excellent cis-selectivity. Upon applying this reaction system, an efficient asymmetric synthesis of β-lactams was accomplished, when chiral acid chlorides or chiral aldehydes were used. These optically active β-lactams would be useful precursors for the generation of combinatorial libraries of potential antibiotics and enzyme inhibitors.

Studies on β-Lactams: Synthesis of Some Steroid-type Di-β-lactams

Schiff bases (1) on reaction with phenoxyacetyl chloride yield the β-lactam esters (2) which on further hydrolysis under mild basic conditions afford α-(2-oxo-1-azetidino)acetic acids (3).Reaction of the imines (4) with 3 using POCl3 and triethylamine fur