76643-99-7

Upstream product

• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 38858-72-9 1-trimethylsiloxy-3,4-dihydronaphthalene 
• 258822-89-8 3-Phenylsulfenyl-2-(N-cyanoimino)thiazolidine 
• 931-59-9 benzenesulfenyl chloride 

Downstream Products

• 76644-00-3 2,2-Bis-phenylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-ol 
• 76644-01-4 2-(1'-hydroxyethyl)-2-(phenylthio)-1-tetralone 

Relevant academic research and scientific papers

A new sulfenylation reagent, 3-phenylsulfenyl-2-(N- cyanoimino)thiazolidine, and its optically active version

We have developed a new sulfenylation reagent, 3-phenylsulfenyl-2-(N- cyanoimino)thiazolidine 3, that is readily available and stable upon storage. Compound 3 easily reacts with amines or thiols to give the corresponding sulfenamides or asymmetrical disulfides in excellent yields. It was also found that the α-sulfenylation reaction of carbonyl compounds with 3 proceeds smoothly. Furthermore, optically active 4-diphenylmethyl derivative 4 was synthesized as an asymmetric sulfenylation reagent, which realized 96% e.e. upon α-sulfenylation of a cyclic β-keto ester.

A new approach to sulfenylated enolates

Bissulfenylation followed by monodesulfenylation with a Grignard reagent cleanly provides magnesium enolates of α-phenylthiocarbonyl compounds for aldol condensation.