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Usage

Uses

Used in Pharmaceutical Industry:
2-IODO-3-(TRIFLUOROMETHYL)BENZOIC ACID is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-IODO-3-(TRIFLUOROMETHYL)BENZOIC ACID serves as an intermediate, playing a crucial role in the production of agrochemicals designed to enhance crop protection and yield.
Used in Organic Synthesis:
2-IODO-3-(TRIFLUOROMETHYL)BENZOIC ACID is utilized as a building block in organic synthesis, enabling the creation of a wide array of chemical compounds for diverse applications.
Used in Scientific Research:
2-IODO-3-(TRIFLUOROMETHYL)BENZOIC ACID is employed in research settings to explore its potential biological and pharmacological activities, contributing to the advancement of knowledge in the fields of chemistry and biology.

Upstream product

• 313-12-2 2-amino-3-(trifluoromethyl)benzoic acid 

Downstream Products

• 1261827-54-6 methyl 3-trifluoromethyl-2-iodobenzoate 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 1415764-02-1 (4S,5S)-2-(3-(trifluoromethyl)-2-iodophenyl)-4,5-dihydro-4-methyl-5-phenyloxazole 
• 1345961-26-3 2-iodo-N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-(trifluoromethyl)benzamide 
• 1345961-24-1 N-[(S)-{(S)-1-allylpiperidin-2-yl}(phenyl)methyl]-2-iodo 3-(trifluoromethyl)benzamide 
• 1035261-45-0 ethyl 2-(3,3,3-triethoxyprop-1-ynyl)-3-(trifluoromethyl)phenylacetate 
• 1035261-43-8 ethyl 2-(2-iodo-3-(trifluoromethyl)phenyl)acetate 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity

The 2-phenoxybenzamide 1 from the Medicines for Malaria Venture Malaria Box Project has shown promising multi-stage activity against different strains of P. falciparum. It was successfully synthesized via a retrosynthetic approach. Subsequently, twenty-one new derivatives were prepared and tested for their in vitro activity against blood stages of the NF54 strain of P. falciparum. Several insights into structure-activity relationships were revealed. The antiplasmodial activity and cytotoxicity of compounds strongly depended on the substitution pattern of the anilino partial structure as well as on the size of substituents. The diaryl ether partial structure had further impacts on the activity. Additionally, several physicochemical and pharmacokinetic parameters were calculated (log P, log D7.4 and ligand efficiency) or determined experimentally (passive permeability and CYP3A4 inhibition). The tert-butyl-4-{4-[2-(4-fluorophenoxy)-3-(trifluoromethyl)benzamido]phenyl}piperazine-1-carboxylate possesses high antiplasmodial activity against P. falciparum NF54 (PfNF54 IC50 = 0.2690 μM) and very low cytotoxicity (L-6 cells IC50 = 124.0 μM) resulting in an excellent selectivity index of 460. Compared to the lead structure 1 the antiplasmodial activity was improved as well as the physicochemical and some pharmacokinetic parameters.

Palladium-catalyzed annulation reactions of methyl o-halobenzoates with azabicyclic alkenes: A general protocol for the construction of benzo[c]phenanthridine derivatives

The annulation reaction of methyl o-halobenzoates with azabicyclic alkenes proceeds efficiently to give the corresponding benzo[c]phenanthridine derivatives in good to excellent yields using a developed base-free methodology based on our preliminary studies. Thirty-seven application examples validate the compatibility of the present strategy with different groups, particularly with the electron-deficient ones, that are difficult to access using other traditional methods. In addition, annulation reactions with non-symmetric azabicyclic alkenes are achieved in high regioselectivity.

Catalytic enantioselective α-tosyloxylation of ketones using iodoaryloxazoline catalysts: Insights on the stereoinduction process

A family of iodooxazoline catalysts was developed to promote the iodine(III)-mediated α-tosyloxylation of ketone derivatives. The α-tosyloxy ketones produced are polyvalent chiral synthons. Through this study, we have unearthed a unique mode of stereoinduction from the chiral oxazoline moiety, where the stereogenic center alpha to the oxazoline oxygen atom is significant. Computational chemistry was used to rationalize the stereoinduction process. The catalysts presented promote currently among the best levels of activity and selectivity for this transformation. Evaluation of the scope of the reaction is presented.

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.

THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS

The present invention relates to the use of selective P2X7 receptor antagonists of formula (I), or a pharmaceutically acceptable salt or prodrug thereof wherein D, R1 and R2 are as defined in claim 1, for the treatment of neuropathic pain, chronic inflammatory pain, inflammation, neurodegeneration and for promoting neuroregeneration.