313-12-2

Basic information

• Product Name: 2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID
• Synonyms: RARECHEM AL BO 1046;3-(TRIFLUOROMETHYL)ANTHRANILIC ACID;2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID;BUTTPARK 22\07-94;2-Amino-3-(trifluoromethyl)benzoic acid 98%;2-Amino-3-(trifluoromethyl)benzoicacid98%;2-Amino-3-trifluoromethyibenzoic acid;2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID PURUM 98%
• CAS NO: 313-12-2
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.13
• EINECS: 1312995-182-4
• Product Categories: Carboxylic Acids;Phenyls & Phenyl-Het;Benzoic acid;Carboxylic Acids;Phenyls & Phenyl-Het;Benzoic acid series;Fluorine series
• Mol File: 313-12-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 157-160 °C(lit.)
• Boiling Point: 296.9 °C at 760 mmHg
• Flash Point: 133.3 °C
• Appearance: /
• Density: 1.489 g/cm³
• Vapor Pressure: 0.00052mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.51±0.10(Predicted)
• BRN: 2844022
• CAS DataBase Reference: 2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID(313-12-2)
• EPA Substance Registry System: 2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID(313-12-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37
• WGK Germany: 3
• Hazardous Substances Data: 313-12-2(Hazardous Substances Data)

Usage

Uses

A useful intermediate for the syntheses of antimicrobial benzoisothiazolones and dithiobis(benzamides).

InChI:InChI=1/C6H5BClFO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,10-11H

Upstream product

• 444-93-9 2-hydroxyimino-N-(2-trifluoromethyl-phenyl)-acetamide 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 444-93-9 (E)-2-(hydroxyimino)-N-(2-(trifluoromethyl)phenyl)acetamide 
• 67-56-1 methanol 
• 391-12-8 7-trifluoromethylisatin 
• 386-71-0 2-nitro-3-(trifluoromethyl)aniline 

Downstream Products

• 106625-31-4 9-oxo-5-(trifluoromethyl)acridan-4-carboxylic acid 
• 105100-70-7 1,1-dimethylethyl <(S)-2-<<2-<1,3-dioxo-3-(2-thiazolylamino)propyl>-6-(trifluoromethyl)phenyl>amino>-1-ethyl-2-oxoethyl>carbamate 
• 114351-33-6 3-[2-(2-Chloro-2-cyclohexyl-acetylamino)-3-trifluoromethyl-phenyl]-3-oxo-N-thiazol-2-yl-propionamide 
• 114351-34-7 2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide 
• 114350-94-6 2-(Cyclohexyl-hydroxy-methyl)-4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid thiazol-2-ylamide 
• 114351-44-9 3-Cyclohexyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol 
• 114350-95-7 4-Hydroxy-2-(hydroxy-phenyl-methyl)-8-trifluoromethyl-quinoline-3-carboxylic acid thiazol-2-ylamide 
• 114351-45-0 3-Phenyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol 
• 190845-21-7 2-(2-Hydroxymethyl-6-trifluoromethyl-phenylamino)-benzoic acid methyl ester 
• 188054-39-9 2-(2-Formyl-6-trifluoromethyl-phenylamino)-benzoic acid methyl ester 
• 95632-28-3 8-Trifluoromethyl-2-(2-trifluoromethyl-phenyl)-benzo[d][1,3]oxazin-4-one 
• 188054-32-2 3-(trifluoromethyl)-2-{[2-(methoxycarbonyl)phenyl]amino}benzoic acid 

Relevant articles and documents

Benzenesulfonamide IDH mutant inhibitor, preparation method and application thereof

The invention discloses a benzenesulfonamide compound represented by a general formula (I) or a pharmaceutically acceptable salt thereof, a preparation method and application thereof. Compared with the prior art, the benzenesulfonamide compound disclosed by the invention can be used as an isocitrate dehydrogenase 2 (IDH2) mutant inhibitor. According to the invention, pharmacological experiment results show that the compound disclosed by the invention has an obvious inhibiting effect on the activity of an IDH2 mutant (mIDH2), can effectively inhibit the process of catalyzing alpha-ketoglutaricacid to generate 2-hydroxyglutaric acid by mIDH2, and can be used for preventing and/or treating various related diseases including cancers and the like caused by IDH2 mutation.

Antimicrobial activity of fluorinated 1,2-benzisothiazol-3(2H)-ones and 2,2'-dithiobis(benzamides)

Fluoro and trifluoromethyl derivatives of 1,2-benzisothiazol-3(2H)-ones and the 2,2'-dithiobis(benzamides) have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were found highly active against fungi and Gram-positive microorganisms and a few derivatives displayed some activity against Gram-negative strains. Structure-activity relationships are proposed.

Oxidation von Isatinen zu Anthranilsaeureestern

-