76655-07-7Relevant academic research and scientific papers
Kinetics of reactions of acyl isothiocyanates with amines
Imrich, Jan,Kristian, Pavol,Podhradsky, Dusan,Dzurilla, Milan
, p. 2334 - 2342 (2007/10/02)
The kinetics of reactions of 4-substituted benzoyl, cinnamoyl and phenyl isothiocyanates with aliphatic amines and glycine ethyl ester in organic solvents was studied by the stopped-flow and UV spectroscopic methods.The reaction of acyl isothiocyanates with the nucleophilic reagents employed proved to be 103-104 times faster than analogous reaction of phenyl isothiocyanates.A linear correlation between log k and ?p constants with positive ? slope was found.The solvent polarity has only a negligible effect on the reaction.UV spectra as well as gas chromatography of the reaction products proved that under the employed experimental conditions N,N'-disubstituted thioureas are the sole reaction products.
