766557-52-2Relevant academic research and scientific papers
Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid
Stansfield, Ian,Avolio, Salvatore,Colarusso, Stefania,Gennari, Nadia,Narjes, Frank,Pacini, Barbara,Ponzi, Simona,Harper, Steven
, p. 5085 - 5088 (2007/10/03)
The discovery of a simple 2-thienyl substituted 5,6-dihydroxypyrimidine-4- carboxylic acid active-site inhibitor of the HCV NS5B polymerase inhibitor is reported. Structure-activity relationships that led to an understanding of the pharmacophore around the pyrimidine ring is also described.
