7666-51-5

Upstream product

• 7142-72-5 N-benzyloxamic acid ethyl ester 
• 74-89-5 methylamine 
• 75102-43-1 3-Methyl-2-phenylthiazolidine-4,5-dione 
• 100-46-9 benzylamine 

Downstream Products

• 56904-09-7 N-methyl-2-(benzylamino)ethylamine 
• 7666-52-6 5-chloro-1-methyl-2-phenylimidazole 
• 105900-08-1 1-Benzyl-3-methyl-1,3-diazolidine 

Relevant academic research and scientific papers

Synthesis of 1,3-Disubstituted Diazolidines

Symmetrical and unsymmetrical 1,3-diaminoethanes 1 are obtained by the reduction of N,N'-disubstituted oxamides 4 with lithium aluminum hydride.The oxamides 4 are readily produced by treatment of diethyl oxalate with primary amines.The 1,3-diaminoethanes 1 lead to 1,3-diazolidines 2 on treatment with formaldehyde.

Reaction of Mesoionic Thiazolones with m-Chloroperbenzoic Acid. Oxidative Dipole Extensions

The oxidation of anhydro-4-hydroxy-2,3,5-triarylthiazolium hydroxides (1) with m-chloroperbenzoic acid gave (in primary alcohols) 2,5-dialkoxy-2,3,5-triarylthiazolidin-4-ones (5) and N-aroylthiobenzanilides (6).Oxidation of anhydro-5-hydroxy-3-methyl-2-phenylthiazolium hydroxide (2) gave 3-methyl-2-phenylthiazolidine-4,5-dione (8) and N-formyl-N-methylthiobenzamide (9).The products arise from initial oxidations at the carbon atoms at position 5 of 1 and position 4 of 2, and transformation modes to the final products are discussed.These oxidations are the first examples of oxidative dipole extensions.