76660-37-2

Usage

Uses

Used in Medicinal Chemistry:
4-(5-bromopyrimidin-2-yloxy)benzenamine is used as a building block in the synthesis of biologically active molecules for medicinal chemistry. Its structural features make it a promising candidate for the development of new pharmaceuticals.
Used in Drug Development:
In the pharmaceutical industry, 4-(5-bromopyrimidin-2-yloxy)benzenamine is utilized as a key intermediate in the creation of novel drugs. Its potential applications in drug development hinge on further research and testing to explore its specific properties and therapeutic effects.

InChI:InChI=1/C10H8BrN3O/c11-7-5-13-10(14-6-7)15-9-3-1-8(12)2-4-9/h1-6H,12H2

Upstream product

• 123-30-8 4-amino-phenol 
• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 100-02-7 4-nitro-phenol 
• 1185158-29-5 4-(5-bromo-2-pyrimidyloxy)aniline 

Relevant academic research and scientific papers

hTERT MODULATORS AND METHODS OF USE

The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.

Aryloxy anilino propionic ester compound and application thereof as herbicide

An aryloxy anilino propionic ester compound comprises the structure shown in the general formula (I), wherein Ar is aromatic heterocycle or fused heterocycle. Please see the specification for the chemical formula of the aromatic heterocycle and the chemical formula of the fused heterocycle, wherein R1, R2, R3 and R4 are one or more of H, halogen, nitro, methoxy group, methyl, methyl formate group, cyanogroup and trihalomethyl, R5 is the alkyl group on the linear chain or branched chain of H and C1-C4, hydrogen on the alkyl group is substituted by hydroxyl, carboxyl, mercapto group, amino, guanidyl and phenyl, and R6 is one of methyl, ethyl, butyl and the substance specified in the specification. The compound has the advantages that the characteristics of being efficient, capable of acting quickly and not prone to resistance generation of (aryloxy) phenoxypropionate herbicides can be maintained, amino acid functional groups in molecules can be designed to serve as adulterate amino acid so as to restrain the biosynthesis of protein of plants, and all weeds can be controlled.

Benzoylphenylurea sulfur analogues with potent antitumor activity

A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to 1 (NSC-639829), against cancer cell lines. 6n was