76660-37-2

Basic information

• Product Name: 4-(5-bromopyrimidin-2-yloxy)benzenamine
• Synonyms: 4-[(5-Bromo-2-pyrimidinyl)oxy]aniline;4-[(5-bromo-2-pyrimidinyl)oxy]Benzenamine;4-(5-bromopyrimidin-2-yloxy)benzenamine;4-(5-Bromopyrimidin-2-yloxy)phenylamine
• CAS NO: 76660-37-2
• Molecular Formula: C₁₀H₈BrN₃O
• Molecular Weight: 266.09
• EINECS: 604-604-1
• Mol File: 76660-37-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 67-69°
• Boiling Point: 445.228ºC at 760 mmHg
• Flash Point: 223.066ºC
• Appearance: /
• Density: 1.613g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.659
• PKA: 3.67±0.10(Predicted)
• CAS DataBase Reference: 4-(5-bromopyrimidin-2-yloxy)benzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-bromopyrimidin-2-yloxy)benzenamine(76660-37-2)
• EPA Substance Registry System: 4-(5-bromopyrimidin-2-yloxy)benzenamine(76660-37-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 76660-37-2(Hazardous Substances Data)

Usage

General Description

4-(5-bromopyrimidin-2-yloxy)benzenamine is a chemical compound with the molecular formula C11H8BrN3O. It is a complex organic molecule containing a benzene ring attached to an amine group and a pyrimidine ring with a bromine atom. 4-(5-bromopyrimidin-2-yloxy)benzenamine has potential applications in medicinal chemistry and drug development due to its structural features. It may be used as a building block in the synthesis of biologically active molecules or pharmaceuticals. The specific properties and uses of 4-(5-bromopyrimidin-2-yloxy)benzenamine would depend on further research and testing.

InChI:InChI=1/C10H8BrN3O/c11-7-5-13-10(14-6-7)15-9-3-1-8(12)2-4-9/h1-6H,12H2

Upstream product

• 123-30-8 4-amino-phenol 
• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 1185158-29-5 4-(5-bromo-2-pyrimidyloxy)aniline 
• 100-02-7 4-nitro-phenol 

Relevant articles and documents

hTERT MODULATORS AND METHODS OF USE

The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.

Benzoylphenylurea sulfur analogues with potent antitumor activity

A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to 1 (NSC-639829), against cancer cell lines. 6n was