767-01-1

Basic information

• Product Name: Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI)
• Synonyms: Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI);2-(chloromethyl)-5-methylpyridine;Pyridine, 2-(chloroMethyl)-5-Methyl-
• CAS NO: 767-01-1
• Molecular Formula: C₇H₈ClN
• Molecular Weight: 141.6
• Product Categories: PYRIDINE
• Mol File: 767-01-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 212℃
• Flash Point: 102℃
• Appearance: /
• Density: 1.118
• Vapor Pressure: 0.253mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI)(767-01-1)
• EPA Substance Registry System: Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI)(767-01-1)

Safety Data

• Hazardous Substances Data: 767-01-1(Hazardous Substances Data)

Usage

General Description

Pyridine, 2-(chloromethyl)-5-methyl- (6CI,7CI,8CI,9CI) is a chemical compound with a specialized structure, consisting of the heterocyclic organic compound known as pyridine with additional chloromethyl and methyl groups. Its presence of chlorine makes it a potentially useful reagent in the field of synthetic chemistry for halogenation reactions. While its specific applications can vary, like many similar compounds, it is likely to be utilized in the creation of other complex organic compounds, and in laboratory research. However, as with many chemical substances, this compound should be handled with care to prevent direct contact, inhalation or ingestion, due to possible toxic or harmful properties. Uses of all chemicals should follow standard safety protocols and specific regulatory guidelines.

InChI:InChI=1/C7H8ClN/c1-6-2-3-7(4-8)9-5-6/h2-3,5H,4H2,1H3

Upstream product

• 4986-05-4 2,5-dimethylpyridine N-oxide 
• 772-71-4 2-acetoxymethyl-5-methyl pyridine 
• 22940-71-2 2-hydroxymethyl-5-methylpyridine 

Downstream Products

• 38203-08-6 5-methyl-2-pyridineacetonitrile 
• 1031435-53-6 3-{3-tert-butylsulfanyl-5-(5-methyl-pyridin-2-ylmethoxy)-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid ethyl ester 
• 65820-21-5 dl-1-[4-(5-methyl-pyridin-2-ylmethoxy)-phenyl]-2-(3,3-diphenylpropylamino)propane maleate 
• 589-93-5 2,5-dimethylpyridine 
• 5552-82-9 ethyl 2-(5-methylpyridin-2-yl)acetate 

Relevant articles and documents

Rapid and Effective Reaction of 2-Methylpyridin-N-oxides with Triphosgene via a [3,3]-Sigmatropic Rearrangement: Mechanism and Applications

A facile and effective synthesis of 2-chloromethylpyridines was developed by a one-pot reaction of 2-alkylpyridin-N-oxides and triphosgene at room temperature. As starting materials, N-oxides of 2-alkylpyridine derivatives, including 2-alkylpyridines, 2-methyl quinolines, and phenanthroline, can react rapidly with triphosgene in the presence of triethylamine, affording 2-chloromethylpyridines in good to excellent yields (52-95%). Using the 2-methylquinoline substrate for the mechanistic study, it has been well demonstrated that the chlorination reaction undergoes a [3,3]-sigmatropic rearrangement, which can be observed as a reversible process by monitoring the intermediates. Moreover, the chlorination reaction can be used to construct a rapid and sensitive fluorescent probe for the detection of phosgene.

PYRIDINE DERIVATIVES SUBSTITUTED BY HETEROCYCLIC RING AND PHOSPHONOAMINO GROUP, AND ANTI-FUNGAL AGENT CONTAINING SAME

Anti-fungal agent having excellent anti-fungal action physicochemical properties including safety and water solubility. Compound represented by formula (I), or salt thereof: wherein R1 represents hydrogen, halogen, amino, R11-NH- wherein R11 represents C1-6 alkyl, hydroxy C1-6 alkyl, C1-6 alkoxy C1-6 alkyl, or C1-6alkoxycarbonyl C1-6 alkyl, R12-(CO)-NH- wherein R12 represents C1-6 alkyl group or C1-6 alkoxy C1-6 alkyl, C1-6 alkyl, hydroxy C1-6 alkyl, cyano C1-6 alkyl, C1-6 alkoxy, or C1-6 alkoxy C1-6 alkyl or a phosphonoamino group; R2 represents hydrogen, C1-6 alkyl, amino, or a di C1-6 alkylamino group or a phosphonoamino group; one of X and Y is nitrogen while the other is nitrogen or oxygen; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom or 1 or 2 C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, oxygen, sulfur, -CH2O-, -OCH2-, -NH-, -CH2NH-, -NHCH2-, -CH2S-, or -SCH2-; R3 represents hydrogen or halogen or C1-6 alkyl, C3-8 cycloalkyl, C6-10 aryl, a 5- or 6-member heteroaryl group or a 5- or 6-member nonaromatic heterocyclic group which may have 1 or 2 substituents; and R4 represents hydrogen or halogen; provided that either R1 or R2 represents a phosphonoamino group.

Heterocycles substituted pyridine derivatives and antifungal agent containing thereof

An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represented by the following formula (I), or a salt thereof: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkoxy C1-6 alkyl group; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group or a di C1-6 alkylamino group; one of X and Y is a nitrogen atom while the other is a nitrogen atom or an oxygen atom; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom, or 1 or 2 C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, —CH2O—, —OCH2—, —NH—, —CH2NH—, —NHCH2—, —CH2S—, or —SCH2—; R3 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-member heteroaryl group, or 5- or 6-member non-aromatic heterocyclic group which may have 1 or 2 substituents; and R4 represents a hydrogen atom or a halogen atom.