22940-71-2

Basic information

• Product Name: (5-methylpyridin-2-yl)methanol
• Synonyms: (5-methylpyridin-2-yl)methanol;5-methyl-2-Pyridinemethanol;2-Pyridinemethanol, 5-methyl-;(5-Methylpyridin-2-yl)
• CAS NO: 22940-71-2
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.16
• Mol File: 22940-71-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 233.5 °C at 760 mmHg
• Flash Point: 95 °C
• Appearance: /
• Density: 1.092 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (5-methylpyridin-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (5-methylpyridin-2-yl)methanol(22940-71-2)
• EPA Substance Registry System: (5-methylpyridin-2-yl)methanol(22940-71-2)

Safety Data

• Hazardous Substances Data: 22940-71-2(Hazardous Substances Data)

Usage

General Description

"(5-methylpyridin-2-yl)methanol" is a chemical compound with the molecular formula C8H9NO. It is a colorless liquid with a mild, aromatic odor, and it is commonly used in the pharmaceutical and chemical industries. (5-methylpyridin-2-yl)methanol is often utilized as a building block in the synthesis of various pharmaceuticals and agrochemicals. It can also be used as a reagent in organic synthesis and as a solvent in certain chemical reactions. Additionally, (5-methylpyridin-2-yl)methanol has potential applications in the development of new materials and catalysts. Overall, this chemical compound has a wide range of uses and applications in various industries.

Upstream product

• 772-71-4 2-acetoxymethyl-5-methyl pyridine 
• 4986-05-4 2,5-dimethylpyridine N-oxide 
• 589-93-5 2,5-dimethylpyridine 
• 55876-82-9 5-methyl-2-pyridinecarboxylic acid-ethyl ester 
• 1620-77-5 5-methylpicolinonitrile 

Downstream Products

• 4985-92-6 5-methylpicolinaldehyde 
• 767-01-1 5-methyl-pyridin-2-ylmethyl chloride 
• 38203-08-6 5-methyl-2-pyridineacetonitrile 
• 5552-82-9 ethyl 2-(5-methylpyridin-2-yl)acetate 
• 589-93-5 2,5-dimethylpyridine 
• 1227563-74-7 2-(bromomethyl)-5-methylpyridine 
• 38076-77-6 3-carboxy-2-hydroxy-5-methyl pyridine 
• 71670-70-7 2-(chloromethyl)-5-methyl-pyridine monohydrochloride 

Relevant articles and documents

Methyl Scanning and Revised Binding Mode of 2-Pralidoxime, an Antidote for Nerve Agent Poisoning

Organophosphorus nerve agents (OPNAs) inhibit acetylcholinesterase (AChE) and, despite the Chemical Weapons Convention arms control treaty, continue to represent a threat to both military personnel and civilians. 2-Pralidoxime (2-PAM) is currently the only therapeutic countermeasure approved by the United States Food and Drug Administration for treating OPNA poisoning. However, 2-PAM is not centrally active due to its hydrophilicity and resulting poor blood-brain barrier permeability; hence, these deficiencies warrant the development of more hydrophobic analogs. Specifically, gaps exist in previously published structure activity relationship (SAR) studies for 2-PAM, thereby making it difficult to rationally design novel analogs that are concomitantly more permeable and more efficacious. In this study, we methodically performed a methyl scan on the core pyridinium of 2-PAM to identify ring positions that could tolerate both additional steric bulk and hydrophobicity. Subsequently, SAR-guided molecular docking was used to rationalize hydropathically feasible binding modes for 2-PAM and the reported derivatives. Overall, the data presented herein provide new insights that may facilitate the rational design of more efficacious 2-PAM analogs.

Deuterium-Substituted Pyridin- And Pyrimidin-2-yl-Methylamine Compounds

Described are deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds of structural Formula (I), which are agonists of 5-hydroxytryptamine receptors. Also described are pharmaceutical compositions comprising the deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds, and methods of use thereof.

5-Lipoxygenase-Activating Protein Inhibitor

Described herein is the FLAP inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, or a pharmaceutically acceptable salt thereof. Also described are methods of p