767-11-3

Usage

Uses

Used in Pharmaceutical Industry:
7-Oxabicyclo[4.1.0]heptane-3-methanol is used as a synthetic intermediate for the synthesis of various drugs and pharmaceutical compounds. Its unique ring structure and alcohol functional group contribute to the development of new and effective medications.
Used in Chemical Research and Development:
7-Oxabicyclo[4.1.0]heptane-3-methanol is used as a solvent and reagent in various laboratory processes, supporting chemical research and development efforts to create new compounds and materials.
Used in Organic Chemistry:
7-Oxabicyclo[4.1.0]heptane-3-methanol is used as a building block in organic chemistry, enabling the creation of complex molecules and contributing to advancements in the field.

Upstream product

• 72581-32-9 cyclohex-3-enylmethanol 

Downstream Products

• 75228-31-8 Acetic acid (1S,3S,6R)-1-(7-oxa-bicyclo[4.1.0]hept-3-yl)methyl ester 

Relevant academic research and scientific papers

Epoxidation of olefins with a silica-supported peracid

Anhydrous [2-percarboxyethyl] functionalized silica (2a) is an advantageous oxidant for performing the epoxidation of olefins 1. Epoxides 3 do not undergo the ring-opening reactions catalyzed by the acidic silica surface, except for particularly activated cases such as styrene oxide. The hydrophilic and acidic character of the silica surface does not interfere with the directing effects exerted by allylic H-bond acceptor substituents. The alkenes 1 carrying hydroxyl groups react with silica-supported peracid 2a faster than unsubstituted alkenes, thus reversing the trend known for reactions with soluble peracids. These results are attributed to the H-bond interactions of substrate 1 with the silanol and carboxylic acid groups bonded to the silica surface.

Vinyl ether compounds and polymerizable compositions

Disclosed is an oxetane-containing vinyl ether compound including one or more aromatic or non-aromatic carbocycles and/or two or more vinyl ether structures, such as a compound of Formula: wherein Ring Z1 is non-aromatic carbocycle; Ra is vinyl group of Formula: wherein each of R1, R2, and R3 is hydrogen or C1-C4 alkyl; Wa is single bond or organic group having a valence of (m+1); X1 is, for example, hydrocarbon; "m" and "q" are each 1 or 2; and "p" is 0 to 5. Also disclosed is an alicyclic epoxy-containing vinyl ether compound of Formula: wherein Ring Z2 is non-aromatic carbocycle; Rb is vinyl group of Formula: wherein R4, R5 and R6 are each hydrogen or C1-C4 alkyl; Wb is single bond or organic group having a valence of (r+1); Rc and Rd are hydrogen or alkyl; and "r" and "s" are 1 or 2.

Diamine derivatives

A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

In vitro mutagenicity and metabolism of the cycloaliphatic epoxy Cyracure UVR 6105

Cyracure UVR 6105 is a cycloaliphatic epoxy monomer and has both carboxylate and epoxy groups, with the potential for rapid polymerization. It is widely used in industry for the preparation of inks, resins, coatings, and was proposed for incorporation into dental composites. The objective of this study was to determine the mutagenic potential of this chemical related to its metabolite products. Several doses of Cyracure UVR 6105 were dissolved in DMSO and subjected to the Ames Salmonella mutagenicity assay. A metabolic activation system (S9-mix) was used consisting of Arochlor-induced liver S9 homogenate enriched with NADP and glucose-6-phosphate cofactors. In contrast to studies without S9-mix, Cyracure UVR 6105 exhibited enhanced genotoxic activities with strains TA100 and TA1535 in the presence of liver S9-mix. From in vitro metabolism of Cyracure UVR 6105 with S9-mix, as used in the Ames assay, several metabolites were identified. The alcohol metabolite, 3,4-epoxycyclohexylmethanol, containing intact epoxy group was identified in the organic solvent extract. This metabolite was synthesized and proved to be mutagenic against TA100 when assayed in the presence and absence of S9-mix. Results showed that the increased mutagenicity of Cyracure UVR-6105 in the presence of liver enzymes is due to the formation of the mutagenic metabolite 3,4-epoxycyclohexylmethanol.

ETHYLENEDIAMINE DERIVATIVES

The invention relates a compound represented by the formula (1):Q1-Q2-C(=O)-N(R1)-Q3-N(R2)-T1-Q4 wherein R1 and R2 represent H or the like; Q1 represents an aromatic ring, heterocyclic ring or the like; Q2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q3 represents a group or the like, Q4 represents an aromatic ring, heterocyclic ring or the like; and T1 represents -CO- or -SO2-, and a medicine which comprises the compound and is useful for thrombosis and embolism.

Methyltrioxorhenium-catalysed epoxidation of alkenes: Enhancement of reactivity in hexafluoro-2-propanol

Methyltrioxorhenium-catalysed epoxidation of alkenes with hydrogen peroxide can be improved by using hexafluoro-2-propanol as a solvent. Quantitative conversions of cyclic and terminal olefins can be obtained with only 30% H2O2 and 0.1 mol% of catalyst.

Design of fluoroketones as efficient reagents for epoxidation reactions in hexafluoropropan-2-ol

Comparative studies on mediated epoxidation reaction using Oxone as primary oxidant and various fluoroketones as reagents, revealed that ketone 3 is very efficient, in particular when used in hexafluoroisopropanol (HFIP) as solvent. It does not suffer from Baeyer-Villiger reaction and can be used in a catalytic amount (1-5mol%) with only 1.5equiv. of Oxone. The reaction gave good yields of epoxides for a number of olefin substrates, included low reactive ones.

Hexafluoroacetone in hexafluoro-2-propanol: A highly active medium for epoxidation with aqueous hydrogen peroxide

The combination of hexafluoro-2-propanol and catalytic amounts of hexafluoroacetone gives a versatile medium for epoxidation of a wide range of alkenes with aqueous hydrogen peroxide.

Epoxidation of olefins with formamide - Hydrogen peroxide

Olefins are converted to epoxides in aqueous medium using formamide-hydrogen peroxide as oxidant.