767-88-4

Basic information

• Product Name: 1-Methyl-3-cyanopyridine-2(1H)-one
• Synonyms: 1,2-Dihydro-1-methyl-2-oxo-3-pyridinecarbonitrile;1-Methyl-3-cyanopyridine-2(1H)-one;Ricinidine;1-Methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
• CAS NO: 767-88-4
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.14
• Mol File: 767-88-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 140°C
• Boiling Point: 247.23°C (rough estimate)
• Appearance: /
• Density: 1.2296 (rough estimate)
• Refractive Index: 1.5880 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Methyl-3-cyanopyridine-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-3-cyanopyridine-2(1H)-one(767-88-4)
• EPA Substance Registry System: 1-Methyl-3-cyanopyridine-2(1H)-one(767-88-4)

Safety Data

• Hazardous Substances Data: 767-88-4(Hazardous Substances Data)

Usage

Uses

1-Methyl-2-oxopyridine-3-carbonitrile is used in the preparations of isoquinuclidines.

Upstream product

• 20577-27-9 pyrid-2-one-3-carbonitrile 
• 74-88-4 methyl iodide 
• 79138-28-6 1-methyl-2-oxo-1,2-dihydropyridine-3-carbaldehyde 
• 61856-47-1 3-formyl-1-methyl-2(1H)-pyridinethione 
• 91584-69-9 1-methyl-3-aldoximido-2(1H)-pyridone 
• 1004-16-6 3-cyano-1-methylpyridinium iodide 
• 769-09-5 1-methyl-2-oxopyridine-3-carboxamide 

Downstream Products

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 130879-54-8 1-methyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile 

Relevant articles and documents

Direct Pd(II)-Catalyzed Site-Selective C5-Arylation of 2-Pyridone Using Aryl Iodides

A straightforward Pd(II)-catalyzed general strategy was developed for the C5-selective arylation of the 2-pyridone core with easily available aryl iodides. The transformation was highly regioselective and accomplished with a wide scope and functional group tolerance. Silver nitrate played a crucial role in this direct site-selective arylation. The method was extended to synthesize biologically active molecules.